Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the retina.Current research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal degeneration.In this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just emerged.While knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and progression.Here,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular degeneration.Further,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

Department of Ophthalmology and Ross Eye Institute,Jacobs School of Medicine and Biomedical Sciences,University at Buffalo,State University of New York,Buffalo,NY,USA;Research Service,Veterans Administration Western New York Healthcare System,Buffalo,NY,USA;Department of Biochemistry,Jacobs School of Medicine and Biomedical Sciences,University at Buffalo,State University of New York,Buffalo,NY,USA

[1]Aneliya Hanineva;Karen Sophia Park;Joshua J.Wang;Margaret M.DeAngelis;Michael H.Farkas;Sarah X.Zhang-.Emerging roles of circular RNAs in retinal diseases)[J].中国神经再生研究（英文版）,2022(09):1875-1880

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