典型文献
Mechanisms of microRNA action in rectal cancer radiotherapy
文献摘要：
Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.
文献关键词：
MicroRNAs;Rectal cancer;Radiotherapy;Mechanisms
中图分类号：
作者姓名：
Zhu Lili;Wang Mojin;Chen Na;Zhang Yujie;Xu Tao;Zhuang Wen;Xiao Shuomeng;Dai Lei
作者机构：
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China;State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China;Department of Gastrointestinal Surgery, Sichuan Cancer Hospital and Institute, Chengdu, Sichuan 610041, China
文献出处：
引用格式：
[1]Zhu Lili;Wang Mojin;Chen Na;Zhang Yujie;Xu Tao;Zhuang Wen;Xiao Shuomeng;Dai Lei-.Mechanisms of microRNA action in rectal cancer radiotherapy)[J].中华医学杂志（英文版）,2022(17):2017-2025
A类：
radioresistance,radiotherapeutic
B类：
Mechanisms,microRNA,action,cancer,Preoperative,neoadjuvant,chemoradiotherapy,combined,total,mesorectal,excision,has,become,standard,treatment,advanced,localized,RC,However,biological,complexity,heterogeneity,tumors,may,contribute,recurrence,metastasis,patients,resistant,identification,factors,leading,radiosensitivity,critical,identify,responsive,improve,outcomes,MicroRNAs,miRNAs,are,small,endogenous,noncoding,that,affect,various,cellular,molecular,targets,have,been,shown,play,important,roles,multiple,processes,associated,In,this,review,summarized,signaling,pathways,including,apoptosis,autophagy,cycle,damage,repair,proliferation,during,Also,evaluated,potential,biomarkers,Rectal,Radiotherapy
AB值：
0.617002
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