典型文献
KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma
文献摘要：
As a member of the potassium calcium-activated channel subfamily,increasing evidence suggests that KCNN4 was associated with malignancies.However,the roles and regulatory mechanisms of KCNN4 in PDAC have been little explored.In this work,we demonstrated that the level of KCNN4 in PDAC was abnormally elevated,and the overexpression of KCNN4 was induced by transcription factor AP-1.KCNN4 was closely correlated with unfavorable clinicopathologic characteristics and poor survival.Functionally,we found that overexpression of KCNN4 promoted PDAC cell proliferation,migration and invasion.Conversely,the knockdown of KCNN4 attenuated the growth and motility of PDAC cells.In addition to these,knockdown of KCNN4 promoted PDAC cell apoptosis and led to cell cycle arrest in the S phase.In mechanistic investigations,RNA-sequence revealed that the MET-mediated AKT axis was essential for KCNN4,encouraging PDAC cell proliferation and migration.Collectively,these findings reveal a function of KCNN4 in PDAC and suggest it's an attractive therapeutic target and tumor marker.Our studies underscore a better understanding of the biological mechanism of KCNN4 in PDAC and suggest novel strategies for cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Xiao Mo;Cheng-fei Zhang;Ping Xu;Min Ding;Zhi-jie Ma;Qi Sun;Yu Liu;Hong-kai Bi;Xin Guo;Alaa Abdelatty;Chao Hu;Hao-jun Xu;Guo-ren Zhou;Yu-liang Jia;Hong-ping Xia
作者机构：
Sir Run Run Hospital,Nanjing Medical University,Nanjing 211166,China;School of Basic Medical Sciences&State Key Laboratory of Reproductive Medicine&Key Laboratory of Antibody Technique of National Health Commission&Jiangsu Antibody Drug Engineering Research Center,Nanjing Medical University,Nanjing 210092,China;Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing 210092,China;Yijishan Hospital of Wannan Medical College,Wannan Medical College,Wuhu 241002,China
文献出处：
引用格式：
[1]Xiao Mo;Cheng-fei Zhang;Ping Xu;Min Ding;Zhi-jie Ma;Qi Sun;Yu Liu;Hong-kai Bi;Xin Guo;Alaa Abdelatty;Chao Hu;Hao-jun Xu;Guo-ren Zhou;Yu-liang Jia;Hong-ping Xia-.KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma)[J].中国药理学报（英文版）,2022(03):735-746
A类：
KCNN4
B类：
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AB值：
0.520892
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