Background: Deoxynivalenol (DON) is one of the most common environmental pollutants that induces intestinal inflammation and microbiota dysbiosis. Lactobacillus rhamnosus GG (LGG) is a probiotic that not only has anti-inflam-matory effects, but also shows protective effect on the intestinal barrier. However, it is still unknown whether LGG exerts beneficial effects against DON-induced intestinal damage in piglets. In this work, a total of 36 weaned piglets were randomized to one of four treatment groups for 21 d. The treatment groups were CON (basal diet); LGG (basal diet supplemented with 1.77 × 1011 CFU/kg LGG); DON (DON-contaminated diet) and LGG + DON (DON-contami-nated diet supplemented with 1.77 × 1011 CFU/kg LGG). Result: Supplementation of LGG can enhance growth performance of piglets exposed to DON by improving intestinal barrier function. LGG has a mitigating effect on intestinal inflammation induced by DON exposure, largely through repression of the TLR4/NF-κB signaling pathway. Furthermore, supplementation of LGG increased the rela-tive abundances of beneficial bacteria (e.g., Collinsella, Lactobacillus, Ruminococcus_torques_group and Anaerofustis), and decreased the relative abundances of harmful bacteria (e.g., Parabacteroides and Ruminiclostridium_6), and also promoted the production of SCFAs. Conclusions: LGG ameliorates DON-induced intestinal damage, which may provide theoretical support for the appli-cation of LGG to alleviate the adverse effects induced by DON exposure.

Yongsong Bai;Kaidi Ma;Jibo Li;Zhongshuai Ren;Jing Zhang;Anshan Shan

Institute of Animal Nutrition,Northeast Agricultural University, Harbin 150030,P.R.China;College of Animal Sciences,Jilin University,Key Laboratory of Zoonosis Research,Ministry of Education,Changchun 130062,P.R.China

畜牧与生物技术杂志（英文版）

[1]Yongsong Bai;Kaidi Ma;Jibo Li;Zhongshuai Ren;Jing Zhang;Anshan Shan-.Lactobacillus rhamnosus GG ameliorates DON-induced intestinal damage depending ontheenrichment ofbeneficial bacteria inweaned piglets)[J].畜牧与生物技术杂志（英文版）,2022(06):1840-1856

ontheenrichment,ofbeneficial,inweaned,Anaerofustis

Lactobacillus,rhamnosus,ameliorates,DON,induced,intestinal,damage,depending,bacteria,piglets,Background,Deoxynivalenol,one,most,common,environmental,pollutants,that,induces,inflammation,microbiota,dysbiosis,LGG,probiotic,not,only,has,anti,matory,effects,but,also,shows,protective,barrier,However,still,unknown,whether,exerts,against,In,this,work,total,were,randomized,four,treatment,groups,CON,basal,diet,supplemented,CFU,contaminated,Result,Supplementation,can,enhance,growth,performance,exposed,by,improving,function,mitigating,exposure,largely,through,repression,TLR4,signaling,pathway,Furthermore,supplementation,increased,abundances,Collinsella,Ruminococcus,torques,decreased,relative,harmful,Parabacteroides,Ruminiclostridium,promoted,production,SCFAs,Conclusions,which,may,provide,theoretical,support,appli,cation,alleviate,adverse

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