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典型文献
贝叶斯法与多元线性回归法预测华法林剂量模型的比较研究
文献摘要:
目的:比较缺失华法林相关基因型检测结果的情况下,基于贝叶斯法的Warfarin Dose Cal-culator(WDC)和基于多元线性回归法(MLR)的Warfarin Dosing、IWPC华法林剂量计算器等三种华法林剂量预测辅助工具的预测性能,为无条件进行华法林相关基因型检测地区的患者使用华法林提供准确、适于临床推广的预测工具.方法:计算三种预测工具的平均预测误差(MPE)、均方根误差(RMSE)和预测误差在实际维持剂量±20%范围内的患者百分比,比较它们的华法林剂量预测性能.所有统计学分析均采用SPSS Statistics 26.0软件进行.结果:WDC的Posteriori模块的MPE和RMSE最低且预测误差在实际维持剂量±20%范围内的患者百分比最高,此外WDC的Pri-ori和Posteriori模块的预测精确度显著高于War-farin Dosing和IWPC华法林剂量计算器(P<0.05).结论:临床常用的三种华法林剂量预测辅助工具中,基于贝叶斯法的Warfarin Dose Calcu-lator可能更适合于无条件进行华法林相关基因型检测地区患者的华法林剂量预测.
文献关键词:
华法林;贝叶斯法;多元线性回归法;剂量预测
作者姓名:
温都苏;王毅;孙建军
作者机构:
内蒙古国际蒙医医院药学部,呼和浩特010065 ,内蒙古;内蒙古医科大学药学院,呼和浩特010052 ,内蒙古;内蒙古医科大学附属医院药剂科,呼和浩特010059 ,内蒙古
引用格式:
[1]温都苏;王毅;孙建军-.贝叶斯法与多元线性回归法预测华法林剂量模型的比较研究)[J].中国临床药理学与治疗学,2022(01):33-38
A类:
culator,farin,Calcu
B类:
贝叶斯法,多元线性回归法,华法林,剂量模型,林相,基因型,Warfarin,Dose,WDC,MLR,Dosing,IWPC,剂量计算,计算器,剂量预测,辅助工具,预测性能,无条件,测地,适于,临床推广,预测误差,MPE,RMSE,维持剂量,统计学分析,Statistics,Posteriori,Pri,预测精确度
AB值:
0.245814
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