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Research Progress on the Pharmacological Mechanisms of Chinese Medicines that Tonify Qi and Activate Blood Against Cerebral Ischemia/Reperfusion Injury
文献摘要：
Cerebral ischemia?reperfusion injury (CIRI) refers to a pathological phenomenon that aggravates the injury after the restoration of blood perfusion and oxygen supply to the cerebral ischemia?induced tissues and organs, with a relatively high incidence. The traditional Chinese medicine (TCM) believes that Qi deficiency and blood stasis are the cause of CIRI. Therefore, Chinese medicine for tonifying Qi and activating blood is regarded as an important choice for the treatment of CIRI. In recent years, it has been found that many Chinese herbal medical ingredients and compound Chinese medicine (CCM) have significant anti?CIRI effects, and their mechanisms of action mainly include improving brain blood supply, neuroprotection, regulating signal pathways such as TLR4/HO?1/Bcl?2, protecting mitochondrial function, regulating related protein levels, and regulating oxidative molecule levels. This article summarizes and introduces the pharmacological mechanisms of Tonifying?Qi and activating?blood Chinese medicine and CCM which have the function of anti?CIRI. Our goal is to provide effective reference for further researches on the cerebral protection of related TCMs or compounds and their clinical application.
文献关键词：
中图分类号：
[1] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）
[2] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）
[3] 天文学、地球科学（P） / 地球物理学（P3） / 空间物理（P35）
作者姓名：
Xiao?Yu Zheng;Ye?Hao Zhang;Wen?Ting Song;Dennis Chang;Jian?Xun Liu
作者机构：
Beijing University of Chinese Medicine,Graduate School,Beijing 100029;Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Pharmacology of Chinese Materia,Beijing 100091,China;NICM Health Research Institute,Western Sydney University,Westmead,NSW 2751,Australia
文献出处：
世界中医药杂志（英文版）
引用格式：
[1]Xiao?Yu Zheng;Ye?Hao Zhang;Wen?Ting Song;Dennis Chang;Jian?Xun Liu-.Research Progress on the Pharmacological Mechanisms of Chinese Medicines that Tonify Qi and Activate Blood Against Cerebral Ischemia/Reperfusion Injury)[J].世界中医药杂志（英文版）,2022(02):225-235
A类：
Tonify,Tonifying
B类：
Research,Progress,Pharmacological,Mechanisms,Chinese,Medicines,that,Qi,Activate,Blood,Against,Cerebral,Ischemia,Reperfusion,Injury,ischemia,reperfusion,injury,CIRI,refers,pathological,phenomenon,aggravates,after,restoration,blood,oxygen,supply,cerebral,induced,tissues,organs,relatively,high,incidence,traditional,medicine,believes,deficiency,stasis,are,cause,Therefore,tonifying,activating,regarded,important,choice,treatment,recent,years,has,been,found,many,herbal,medical,ingredients,CCM,have,significant,anti,effects,their,mechanisms,action,mainly,include,improving,brain,neuroprotection,regulating,signal,pathways,such,TLR4,HO,Bcl,protecting,mitochondrial,function,related,protein,levels,oxidative,molecule,This,article,summarizes,introduces,pharmacological,which,Our,goal,provide,effective,reference,further,researches,TCMs,compounds,clinical,application
AB值：
0.61169
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