典型文献
Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with Upper Respiratory Tract Infections:A Multicenter Randomized Controlled Trial
文献摘要：
Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in children.Methods:The study was a multicenter,randomized,open-label,controlled trial.A total of 142 children aged 2 to 14 years old,with URTI-associated cough within 48 h of onset,were randomly assigned to two groups at a 1:1 ratio by computer-generated randomization sequence.Children were treated with JWZH(1 to 1.5 g,twice to thrice daily)in the treatment group or conventional treatment(Pediatric Paracetamol,Artificial Cow-bezoar and Chlorphenamine Maleate Granules,0.25 to 1 g,thrice daily)in the control group for 5 days.The primary endpoints were the time to cough resolution and 4-day cough resolution rate.The secondary endpoints were the daily improvement in symptom scores and cough resolution rate during the study period.Results:A total of 138 children were included in the intention-to-treat analysis,with 71 cases in the treatment group and 67 cases in the control group.Compared with the conventional treatment,the children receiving JWZH had a shorter time to cough resolution[hazard ratio,2.10;95％confidence interval(CI),1.29-3.40;P=0.003].The median time to cough resolution for children receiving JWZH was shorter than that of the conventional treatment(2 days vs.3 days;P＜0.001).The 4-day cough resolution rate in the JWZH group was higher than that of the control group(94.4％vs.74.6％;risk difference:19.8％,95％CI:8.1％-31.5％;relative risk:1.265,95％CI:1.088-1.470;P=0.001).There were no statistically significant differences in the improvement of other symptoms caused by URTI(P＞0.05).Adverse events was reported in 5.6％(4/71)and 4.5％(3/67)in participants of JWZH and PPACCM groups(P＞0.05),respectively,which were all mild and resolved without treatment.Conclusion:JWZH seemed to be a safe and effective therapy for URTI-associated cough in children.
文献关键词：
中图分类号：
作者姓名：
LUO Hui;SONG Gui-Hua;MA Xiao-jian;SUN Meng-meng;ZHANG Man;XIE Jian-rong;PENG Shao
作者机构：
Institute for Tibetan Medicine,China Tibetology Research Center,Beijing,100101,China;Department of Pediatrics,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,450000,China;Department of Pediatrics,Huaihe Hospital of Henan University,Zhengzhou,450000,China;Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,475000,China;School of Statistics,Renmin University of China,Beijing,100872,China
文献出处：
引用格式：
[1]LUO Hui;SONG Gui-Hua;MA Xiao-jian;SUN Meng-meng;ZHANG Man;XIE Jian-rong;PENG Shao-.Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with Upper Respiratory Tract Infections:A Multicenter Randomized Controlled Trial)[J].中国结合医学杂志（英文版）,2022(05):387-393
A类：
Jiuwei,Zhuhuang,JWZH,bezoar,Chlorphenamine,Maleate,PPACCM
B类：
Effect,Powder,Cough,Resolution,Children,Upper,Respiratory,Tract,Infections,Multicenter,Randomized,Controlled,Trial,Objective,To,assess,effectiveness,Tibetan,patent,medicine,treating,upper,respiratory,tract,infection,URTI,associated,cough,children,Methods,study,was,multicenter,randomized,open,label,controlled,trial,total,aged,years,old,within,onset,were,randomly,assigned,two,groups,ratio,by,computer,generated,randomization,sequence,treated,twice,thrice,daily,treatment,conventional,Pediatric,Paracetamol,Artificial,Cow,Granules,days,primary,endpoints,resolution,secondary,improvement,scores,during,period,Results,included,intention,analysis,cases,Compared,receiving,had,shorter,hazard,confidence,interval,median,than,that,higher,risk,relative,There,no,statistically,significant,differences,other,symptoms,caused,Adverse,events,reported,participants,respectively,which,mild,resolved,without,Conclusion,seemed,safe,therapy
AB值：
0.452189
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