典型文献
Small molecules for combating multidrug-resistant superbug Candida auris infections
文献摘要：
Candida auris is emerging as a major global threat to human health.C.auris infections are associated with high mortality due to intrinsic multi-drug resistance.Currently,therapeutic options for the treatment of C.auris infections are rather limited.We aim to provide a comprehensive review of current strategies,drug candidates,and lead compounds in the discovery and development of novel therapeutic agents against C.auris.The drug resistance profiles and mechanisms are briefly summarized.The struc-tures and activities of clinical candidates,drug combinations,antifungal chemosensitizers,repositioned drugs,new targets,and new types of compounds will be illustrated in detail,and perspectives for guiding future research will be provided.We hope that this review will be helpful to prompting the drug devel-opment process to combat this fungal pathogen.
文献关键词：
中图分类号：
作者姓名：
Jie Tu;Na Liu;Yahui Huang;Wanzhen Yang;Chunquan Sheng
作者机构：
School of Pharmacy,Second Military Medical University,Shanghai 200433,China
文献出处：
引用格式：
[1]Jie Tu;Na Liu;Yahui Huang;Wanzhen Yang;Chunquan Sheng-.Small molecules for combating multidrug-resistant superbug Candida auris infections)[J].药学学报（英文版）,2022(11):4056-4074
A类：
superbug,auris,chemosensitizers
B类：
Small,molecules,combating,multidrug,resistant,Candida,infections,emerging,major,global,threat,human,health,are,associated,high,mortality,due,intrinsic,resistance,Currently,therapeutic,options,treatment,rather,limited,We,aim,comprehensive,review,current,strategies,candidates,lead,compounds,discovery,development,novel,agents,against,profiles,mechanisms,briefly,summarized,struc,tures,activities,clinical,combinations,antifungal,repositioned,drugs,new,targets,types,will,be,illustrated,detail,perspectives,guiding,future,research,provided,hope,that,this,helpful,prompting,process,pathogen
AB值：
0.564739
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