典型文献
Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitochondrial function
文献摘要：
Soy consumption has been associated with potential health benefits in reducing chronic diseases. These physiological functions have been attributed to soy proteins or more commonly to bioactive peptides. Thus, more studies are required to identify these bioactive peptides, and elucidate their biological mechanisms of action. In the present study, a novel peptide iglycin was purified from soybean seeds with a molecular mass of 3.88 kDa. Thereafter, iglycin reduced fasting blood glucose and restored insulin sensitivity of C57BL/6J mice on a high-fat diet with increased phosphorylation of insulin receptor substrate 1 (IRS1) and AKT in adipose tissue. Furthermore, it improved glucose uptake, induced translocation of intracellular GLUT4 to plasma membrane and activation of insulin signaling in adipocytes under insulin-resistant condition. In addition, it decreased reactive oxygen species production, lipid peroxidation and inhibited adipocyte apoptosis with improved mitochondrial function as evidenced by up-regulation of succinate dehydrogenase activity, mitochondrial membrane potential and intracellular ATP store. These data suggested that iglycin ameliorated insulin resistance via activation of insulin signaling, which was associated with inhibition of oxidative stress, adipocyte apoptosis, and improvement of mitochondrial function.
文献关键词：
中图分类号：
作者姓名：
Yinghuan Wu;Ran Zhao;Minxia Li;Huiyun Li;Zhengwang Chen;Yanying Zhao
作者机构：
Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Ministry of Education,Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province,College of Life Science and Technology,Southwest Minzu University,Chengdu 610041,China;Shandong Tianheng Inspection Co.,Ltd.,Heze 274000,China;Key Laboratory of Molecular Biophysics of Ministry of Education,School of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China
文献出处：
引用格式：
[1]Yinghuan Wu;Ran Zhao;Minxia Li;Huiyun Li;Zhengwang Chen;Yanying Zhao-.Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitochondrial function)[J].食品科学与人类健康（英文）,2022(06):1565-1572
A类：
iglycin
B类：
Novel,soybean,ameliorates,insulin,resistance,high,fat,diet,fed,C57BL,6J,mice,differentiated,3T3L1,adipocytes,improvement,signaling,mitochondrial,Soy,consumption,has,been,associated,potential,health,benefits,reducing,chronic,diseases,These,physiological,functions,have,attributed,proteins,commonly,bioactive,peptides,Thus,studies,are,required,identify,these,elucidate,their,biological,mechanisms,action,In,present,study,novel,was,purified,from,seeds,molecular,mass,kDa,Thereafter,reduced,fasting,blood,glucose,restored,sensitivity,increased,phosphorylation,receptor,substrate,IRS1,AKT,adipose,tissue,Furthermore,improved,uptake,induced,translocation,intracellular,GLUT4,plasma,membrane,activation,under,resistant,condition,addition,decreased,reactive,oxygen,species,production,lipid,peroxidation,inhibited,apoptosis,evidenced,by,regulation,succinate,dehydrogenase,activity,ATP,data,suggested,that,ameliorated,via,which,inhibition,oxidative,stress
AB值：
0.601534
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