典型文献
Design,synthesis,and bioassay of 5-epi-aminoglycosides
文献摘要：
For the purpose of seeking new antibiotics,researchers usually modify the already-existing ones.However,this strategy has been extensively used and is close to its limits,especially in the case of aminoglycosides,and it is difficult to find a proper aminoglycoside antibiotic for novel modification.In this paper,we reported the design,synthesis,and evaluation of a series of 5-epi-neamine derivatives based on the structural information of bacterial 16S RNA A-site binding with aminoglycosides.Bioassay results showed that our design strategy was feasible.Our study offers a new way to search for structurally novel aminoglycosides.Meanwhile,our study provides valuable structure-activity relationship information,which will lead to better understanding and exploitation of the drug target,and improved development of new aminoglycoside antibiotics.
文献关键词：
中图分类号：
作者姓名：
YAN Ribai;NIU Youhong;LIU Yuheng;DENG Junfeng;YE Xinshan
作者机构：
School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;College of Pharmaceutical Science,Hebei Medical University,Shijiazhuang 050017,China;Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,School of Pharmacy,Chengdu University,Chengdu 610106,China
文献出处：
引用格式：
[1]YAN Ribai;NIU Youhong;LIU Yuheng;DENG Junfeng;YE Xinshan-.Design,synthesis,and bioassay of 5-epi-aminoglycosides)[J].中国天然药物,2022(11):854-862
A类：
neamine,Bioassay
B类：
Design,synthesis,bioassay,epi,aminoglycosides,For,purpose,seeking,new,antibiotics,researchers,usually,modify,already,existing,ones,However,this,strategy,has,been,extensively,used,close,limits,especially,case,difficult,find,proper,novel,modification,In,paper,reported,design,evaluation,series,derivatives,information,bacterial,16S,site,binding,results,showed,that,our,was,feasible,Our,study,offers,way,structurally,Meanwhile,provides,valuable,structure,activity,relationship,which,will,lead,better,understanding,exploitation,drug,target,improved,development
AB值：
0.599781
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