典型文献
Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma
文献摘要：
Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas directly,mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways.IDH mutations mediate immune-cell infiltration and function by modulat-ing immune-checkpoint gene expression and chemokine secretion.In addition,IDH mutation-derived D2-hydrox-yglutarate can be absorbed by surrounding immune cells,also affecting their functioning.In this review,we sum-marize current knowledge about the effects of IDH mutations as well as other gene mutations on the immune microenvironment of gliomas.We also describe recent preclinical and clinical data related to IDH-mutant inhibitors for the treatment of gliomas.Finally,we discuss different types of immunotherapy and the immunothera-peutic potential of IDH mutations in gliomas.
文献关键词：
中图分类号：
作者姓名：
Feng Tang;Zhiyong Pan;Yi Wang;Tian Lan;Mengyue Wang;Fengping Li;Wei Quan;Zhenyuan Liu;Zefen Wang;Zhiqiang Li
作者机构：
Brain Glioma Center and Department of Neurosurgery,Wuhan University Zhongnan Hospital,Wuhan 430071,China;Department of Physiology,Wuhan University School of Basic Medical Sciences,Wuhan 430071,China
文献出处：
引用格式：
[1]Feng Tang;Zhiyong Pan;Yi Wang;Tian Lan;Mengyue Wang;Fengping Li;Wei Quan;Zhenyuan Liu;Zefen Wang;Zhiqiang Li-.Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma)[J].神经科学通报（英文版）,2022(09):1069-1084
A类：
Immunotherapeutic,Isocitrate,modulat,yglutarate,immunothera
B类：
Advances,Potential,Dehydrogenase,Mutations,Glioma,dehydrogenase,IDH,essential,metabolic,enzyme,tricarboxylic,acid,cycle,TAC,high,frequency,gene,plays,complicated,role,gliomas,In,addition,affecting,directly,mutations,can,also,alter,their,immune,microenvironment,change,indirect,ways,mediate,infiltration,by,checkpoint,expression,chemokine,secretion,derived,D2,hydrox,absorbed,surrounding,cells,functioning,this,review,sum,marize,current,knowledge,about,effects,well,We,describe,recent,preclinical,data,related,mutant,inhibitors,treatment,Finally,discuss,different,types,immunotherapy,potential
AB值：
0.490708
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