典型文献
A Comparative Study Between Tumor Blood Vessels and Dynamic Contrast-enhanced MRI for Identifying Isocitrate Dehydrogenase Gene 1(IDH1)Mutation Status in Glioma
文献摘要：
Isocitrate dehydrogenase gene(IDH)mutations are associated with tumor angiogenesis and therefore play an important role in glioma management.This study compared the performance of tumor blood vessels counted from contrast-enhanced 3D brain volume(3D-BRAVO)sequence and dynamic contrast-enhanced(DCE)MRI in differentiating IDH1 status in gliomas.Methods:Forty-four glioma patients[16 with IDH1 mutant-type(IDH1-MT),28 with IDH1 wild-type(IDH1-WT)]were retrospectively analyzed.A blood vessel entering a tumor was defined as an intratumoral vessel;a blood vessel adjacent to the edge of a tumor was defined as a peritumoral vessel.Combined vessels were defined as the sum of the intratumoral and peritumoral vessels.DCE-derived metrics of tumor were normalized to the contralateral normal-appearing white matter.Results:Intratumoral,peritumoral,and combined tumor blood vessels were all significantly different between IDH 1-MT and IDH1-WT gliomas,and the range of area under curves(AUCs)was 0.816-0.855.For DCE-derived parameters,cerebral blood volume,cerebral blood flow,mean transit time,and volume transfer constant were significantly different between IDH 1-MT and IDH1-WT gliomas,and the range of AUCs was 0.703-0.756.Combined vessels possessed the best performance for identifying IDH1 mutations in gliomas(AUC:0.855,sensitivity:0.857,specificity:0.812,P＜0.001).Conclusion:The number of tumor blood vessels has comparable diagnostic performance with DCE-derived parameters for differentiating IDH1 mutations and can serve as a potential imaging biomarker to reflect IDH1 mutations in gliomas.
文献关键词：
中图分类号：
作者姓名：
Shi-hui LI;Nan-xi SHEN;Di WU;Ju ZHANG;Jia-xuan ZHANG;Jing-jing JIANG;Wen-zhen ZHU
作者机构：
Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
文献出处：
引用格式：
[1]Shi-hui LI;Nan-xi SHEN;Di WU;Ju ZHANG;Jia-xuan ZHANG;Jing-jing JIANG;Wen-zhen ZHU-.A Comparative Study Between Tumor Blood Vessels and Dynamic Contrast-enhanced MRI for Identifying Isocitrate Dehydrogenase Gene 1(IDH1)Mutation Status in Glioma)[J].当代医学科学(英文),2022(03):650-657
A类：
Vessels,Isocitrate,peritumoral
B类：
Comparative,Study,Between,Tumor,Blood,Dynamic,Contrast,enhanced,Identifying,Dehydrogenase,Gene,IDH1,Mutation,Status,Glioma,dehydrogenase,mutations,associated,angiogenesis,therefore,play,important,role,management,This,study,compared,performance,blood,vessels,counted,from,contrast,brain,volume,BRAVO,sequence,dynamic,DCE,differentiating,status,gliomas,Methods,Forty,four,patients,mutant,type,MT,wild,WT,were,retrospectively,analyzed,entering,was,defined,intratumoral,adjacent,edge,Combined,sum,derived,metrics,normalized,contralateral,appearing,white,matter,Results,Intratumoral,combined,all,significantly,between,range,area,under,curves,AUCs,parameters,cerebral,flow,mean,transit,transfer,constant,possessed,best,identifying,sensitivity,specificity,Conclusion,number,has,comparable,diagnostic,serve,potential,imaging,biomarker,reflect
AB值：
0.457702
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
