典型文献
Chimeric Antigen Receptors and Regulatory T Cells:The Potential for HLA-Specific Immunosuppression in Transplantation
文献摘要：
Chimeric antigen receptors(CARs)are a breakthrough in genetic engineering that have revolutionized the field of adoptive cellular therapy(ACT).Cells expressing these receptors are rerouted to a predefined tar-get by the inclusion of an antigen-specific binding region within the synthetic CAR construct.The advan-tage of cells with programmed specificity has been demonstrated clinically in the field of oncology,and it is clear that such cells have greater accuracy,potency,and reduced off-target therapeutic effects com-pared with their unmodified counterparts.In contrast to conventional T cells(Tconvs),regulatory T cells(Tregs)play a major role in suppressing immune activation and regulating the host immune response.CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases,graft-versus-host disease(GVHD),and organ transplant rejection.In the latter,they hold immense poten-tial as mediators of immune tolerance for recipients of allotransplants.However,current research into CAR-Treg engineering is extremely limited,and there is uncertainty regarding optimal design for thera-peutic use.This review examines the rationale behind the development of CAR-Tregs,their significance for human transplantation,potential designs,safety considerations,and comparisons of CAR-Tregs in transplantation models to date.
文献关键词：
中图分类号：
作者姓名：
Sabrina Wright;Conor Hennessy;Joanna Hester;Fadi Issa
作者机构：
Nuffield Department of Surgical Sciences,University of Oxford,Oxford OX3 9DU,UK
文献出处：
引用格式：
[1]Sabrina Wright;Conor Hennessy;Joanna Hester;Fadi Issa-.Chimeric Antigen Receptors and Regulatory T Cells:The Potential for HLA-Specific Immunosuppression in Transplantation)[J].工程（英文）,2022(03):30-43
A类：
CARs,rerouted,Tconvs,allotransplants
B类：
Chimeric,Antigen,Receptors,Regulatory,Cells,Potential,HLA,Specific,Immunosuppression,Transplantation,antigen,receptors,breakthrough,genetic,engineering,that,have,revolutionized,field,adoptive,cellular,therapy,ACT,expressing,these,predefined,by,inclusion,binding,region,within,synthetic,construct,advan,tage,cells,programmed,specificity,has,been,demonstrated,clinically,oncology,clear,such,greater,accuracy,potency,reduced,off,target,therapeutic,effects,pared,their,unmodified,counterparts,In,contrast,conventional,regulatory,Tregs,play,major,role,suppressing,activation,regulating,host,response,expression,proposed,autoimmune,inflammatory,diseases,graft,versus,GVHD,organ,rejection,latter,they,hold,immense,mediators,tolerance,recipients,However,current,research,into,extremely,limited,there,uncertainty,regarding,optimal,use,This,review,examines,rationale,behind,development,significance,human,transplantation,potential,designs,safety,considerations,comparisons,models,date
AB值：
0.615229
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