典型文献
Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer's Disease and Attenuate AD-type Pathology in a Mouse Model
文献摘要：
Increased neuronal apoptosis is an important pathological feature of Alzheimer's disease(AD).The Bcl-2-interacting mediator of cell death(Bim)mediates amyloid-beta(Aβ)-induced neuronal apoptosis.Naturally-occurring antibodies against Bim(NAbs-Bim)exist in human blood,with their levels and functions unknown in AD.In this study,we found that circulating NAbs-Bim were decreased in AD patients.Plasma levels of NAbs-Bim were negatively associated with brain amyloid burden and positively associated with cognitive functions.Further-more,NAbs-Bim purified from intravenous immunoglob-ulin rescued the behavioral deficits and ameliorated Aβ deposition,tau hyperphosphorylation,microgliosis,and neuronal apoptosis in APP/PS1 mice.In vitro investiga-tions demonstrated that Nabs-Bim were neuroprotective against AD through neutralizing Bim-directed neuronal apoptosis and the amyloidogenic processing of amyloid precursor protein.These findings indicate that the decrease of Nabs-Bim might contribute to the pathogenesis of AD and immunotherapies targeting Bim hold promise for the treatment of AD.
文献关键词：
中图分类号：
作者姓名：
Jie-Ming Jian;Dong-Yu Fan;Ding-Yuan Tian;Yuan Cheng;Pu-Yang Sun;Cheng-Rong Tan;Gui-Hua Zeng;Chen-Yang He;Ye-Ran Wang;Jie Zhu;Xiu-Qing Yao;Yan-Jiang Wang;Yu-Hui Liu
作者机构：
Department of Neurology and Centre for Clinical Neuro-science,Daping Hospital,Third Military Medical University,Chongqing 400000,China;Shigatse Branch,Xinqiao Hospital,Third Military Medical University,Shigatse 857000,China;Department of Rehabilitation,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400000,China;Key Laboratory of Ageing and Brain Disease,Chongqing 400000,China;Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China
文献出处：
引用格式：
[1]Jie-Ming Jian;Dong-Yu Fan;Ding-Yuan Tian;Yuan Cheng;Pu-Yang Sun;Cheng-Rong Tan;Gui-Hua Zeng;Chen-Yang He;Ye-Ran Wang;Jie Zhu;Xiu-Qing Yao;Yan-Jiang Wang;Yu-Hui Liu-.Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer's Disease and Attenuate AD-type Pathology in a Mouse Model)[J].神经科学通报（英文版）,2022(09):1025-1040
A类：
Attenuate,immunoglob,ulin,microgliosis,Nabs,amyloidogenic
B类：
Naturally,Occurring,Antibodies,Against,Bim,are,Decreased,Alzheimer,Disease,AD,type,Pathology,Mouse,Model,Increased,neuronal,apoptosis,important,pathological,feature,disease,Bcl,interacting,mediator,cell,death,mediates,beta,induced,occurring,antibodies,against,NAbs,exist,human,blood,their,levels,functions,unknown,this,study,found,that,circulating,were,decreased,patients,Plasma,negatively,associated,brain,burden,positively,cognitive,Further,more,purified,from,intravenous,rescued,behavioral,deficits,ameliorated,deposition,tau,hyperphosphorylation,PS1,mice,vitro,investiga,demonstrated,neuroprotective,through,neutralizing,directed,processing,precursor,protein,These,findings,indicate,might,contribute,pathogenesis,immunotherapies,targeting,hold,promise,treatment
AB值：
0.552339
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