典型文献
Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis
文献摘要：
Cerebral ischemia/reperfusion(I/R)is a potential factor for lethal injury,and currently lacks effective remedies.Bauhinia championii extracts(BCEs)have been reported to exhibit anti-oxidative and anti-hypoxia properties.The current work aimed to study whether BCE could alleviate neuronal injury caused by I/R.Methods:To investigate the protective effects of BCE,oxygen-glucose deprivation/reperfusion(OGD/R)was applied to the HT22 cell line in vitro and to a cerebral I/R mouse model in vivo.Results:Under OGD/R,the survival of HT22 cells was significantly prolonged after treatment with BCE.In vivo,BCE significantly reduced the infarct area and decreased neuronal apoptosis caused by I/R.It was further found that OGD/R could trigger endoplasmic reticulum(ER)stress and induce ER stress-mediated neuronal apoptosis in vivo and in vitro,while BCE could effectively alleviate ER stress and neuronal apoptosis.Conclusion:These results suggested that BCE exhibits neuroprotective effects by reducing ER stress-mediated apoptosis after cerebral I/R injury.BCE may therefore be an effective therapeutic regimen against cerebral I/R damage.
文献关键词：
中图分类号：
作者姓名：
Mei HUANG;Zi-xi LI;Juan CHEN;Ling CHEN;Yuan-yuan LI
作者机构：
Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Laboratory Medicine,Affiliated Hospital of Chinese and Western Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Biochemistry and Molecular Biology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;School of Pharmacy,Hangzhou Medical College,Hangzhou 310053,China
文献出处：
引用格式：
[1]Mei HUANG;Zi-xi LI;Juan CHEN;Ling CHEN;Yuan-yuan LI-.Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis)[J].当代医学科学(英文),2022(03):483-490
A类：
Championii,Alleviate
B类：
Extracts,Bauhinia,Acute,Neuronal,Injury,After,Ischemic,Reperfusion,by,Improving,Endoplasmic,Reticulum,Stress,Mediated,Apoptosis,Cerebral,ischemia,reperfusion,potential,lethal,injury,currently,lacks,remedies,championii,extracts,BCEs,have,been,reported,anti,oxidative,hypoxia,properties,work,aimed,study,whether,could,alleviate,neuronal,caused,Methods,To,investigate,effects,oxygen,glucose,deprivation,OGD,was,applied,HT22,line,vitro,cerebral,mouse,model,vivo,Results,Under,survival,cells,significantly,prolonged,after,treatment,reduced,infarct,area,decreased,apoptosis,It,further,found,that,trigger,endoplasmic,reticulum,ER,stress,induce,mediated,while,effectively,Conclusion,These,results,suggested,exhibits,neuroprotective,reducing,may,therefore,therapeutic,regimen,against,damage
AB值：
0.586061
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