典型文献
Clinical practice of rapid antigen tests for SARS-CoV-2 Omicron variant:A single-center study in China
文献摘要：
Responding to the fast-spreading SARS-CoV-2 Omicron variant,to improve screening efficiency,rapid antigen tests(RATs)were first added as a supplementary detection method in China in mid-March,2022.What and how big a role RATs should play need to be supported by clinical data.Here,RAT performance and relevant factors in comparison with nucleic acid amplification tests(NAATs)were assessed in Omicron-infected inpatients.From the NAAT results,nasopharyngeal swabs(NPs)performed better than oropharyngeal swabs(OPs).RATs tested on NAAT positive NPs performed better than those with OP-positive samples.The RAT positivity rate was strongly associated with high levels of N and OFR1ab genes,especially in NPs where patients also had significantly longer hospital stays and shorter days from symptom onset to RAT testing.Self-performed RATs had a detection accuracy that was comparable to professionally performed RATs when the subjects were well guided.The antigen negative rate of the studied patients was 100％at discharge.These findings suggest that,in addition to a supplementary detection role,RATs can be an important strategy for evaluating the disease progression of Omicron-infected inpatients.This study provides important clinical data to support better rules regarding RATs under China's CO VID-19 prevention and control policy.
文献关键词：
中图分类号：
作者姓名：
Mengyuan Chen;Jiaqin Xu;Lingjun Ying;Miaoguo Cai;Tao-Hsin Tung;Kai Zhou;Yufen Zheng;Xiaojie Bi;Jing Wang;Xi Tu;Bo Shen;Dongqing Lv
作者机构：
Department of Laboratory Medicine,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,317000,China;Hepatology and Infectious Diseases Center,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,317000,China;Department of Radiation Oncology,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,317000,China;Evidence-based Medicine Center,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,317000,China;Department of Respiratory and Critical Diseases,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,317000,China
文献出处：
引用格式：
[1]Mengyuan Chen;Jiaqin Xu;Lingjun Ying;Miaoguo Cai;Tao-Hsin Tung;Kai Zhou;Yufen Zheng;Xiaojie Bi;Jing Wang;Xi Tu;Bo Shen;Dongqing Lv-.Clinical practice of rapid antigen tests for SARS-CoV-2 Omicron variant:A single-center study in China)[J].中国病毒学,2022(06):842-849
A类：
Responding,OFR1ab
B类：
Clinical,practice,rapid,antigen,tests,SARS,CoV,Omicron,variant,single,center,study,China,fast,spreading,improve,screening,efficiency,RATs,were,first,added,supplementary,detection,method,mid,March,What,how,big,role,should,play,need,supported,by,clinical,data,Here,performance,relevant,factors,comparison,nucleic,acid,amplification,NAATs,assessed,infected,inpatients,From,results,nasopharyngeal,swabs,NPs,performed,better,than,oropharyngeal,OPs,tested,positive,those,samples,positivity,was,strongly,associated,high,levels,genes,especially,where,also,had,significantly,longer,hospital,stays,shorter,days,from,symptom,onset,testing,Self,accuracy,that,comparable,professionally,when,subjects,well,guided,negative,studied,discharge,These,findings,suggest,addition,important,strategy,evaluating,disease,progression,This,provides,rules,regarding,under,VID,prevention,control,policy
AB值：
0.561879
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