We performed this study to investigate pathological upgrading from biopsy to prostatectomy and clinicopathological factors associated with grade group(GG)upgrading in patients with International Society of Urological Pathology(ISUP)GG 1 and 2 prostate cancer(PCa)in a Chinese cohort.We included patients diagnosed with PCa with ISUP GG 1 and 2 at biopsy,who underwent RP at our institution.Pre-and postoperative clinical variables were examined.Univariate and multivariate logistic regression analyses were conducted to identify independent factors associated with GG upgrading.Patients in GG upgraded group had higher total prostate-specific antigen(tPSA;median:14.43 ng ml-1 vs 10.52 ng ml-1,P=0.001)and PSA density(PSAD;median:0.45 ng ml-2 vs 0.27 ng ml-2,P＜0.001)than those in GG nonupgraded group.Patients in upgraded group had a higher ratio for Prostate Imaging-Reporting and Data System(PI-RADS)score＞3(86.4％vs 67.9％,P＜0.001).Those with GG 1 in biopsy were more likely to experience GG upgrading after RP than those with GG 2(71 vs 54,P=0.016).Independent preoperative factors predicting GG upgrading were PI-RADS score＞3(odds ratio[OR]:2.471,95％confidence interval[CI]:1.132-5.393;P=0.023),higher PSAD(P=0.001),and GG in biopsy(OR:0.241,95％Cl:0.123-0.471;P＜0.001).The histopathological analyses of RP specimens revealed that perineural invasion(PNI;OR:1.839,95％Cl:1.027-3.490;P=0.041)was identified as an independent factor associated with GG upgrading.Our results revealed that GG in the biopsy,PSAD,PI-RADS score＞3,and PNI were independent factors of GG upgrading.These factors should be considered for patients with ISUP grade≤2 PCa.

Xing Li;Zhi-Xian Wang;Yun-Peng Zhu;Jing Wang;Yi-Sheng Yin;Xiao-Yong Zeng

Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

亚洲男性学杂志（英文版）

[1]Xing Li;Zhi-Xian Wang;Yun-Peng Zhu;Jing Wang;Yi-Sheng Yin;Xiao-Yong Zeng-.Clinicopathological factors associated with pathological upgrading from biopsy to prostatectomy in patients with ISUP grade group≤2 prostate cancer)[J].亚洲男性学杂志（英文版）,2022(05):487-493

Clinicopathological,nonupgraded

factors,associated,upgrading,from,biopsy,prostatectomy,patients,ISUP,group,cancer,We,performed,this,study,investigate,clinicopathological,GG,International,Society,Urological,Pathology,PCa,Chinese,cohort,included,diagnosed,who,underwent,RP,our,institution,Pre,postoperative,clinical,variables,were,examined,Univariate,multivariate,logistic,regression,analyses,conducted,identify,independent,Patients,had,higher,total,specific,antigen,tPSA,median,ml,density,PSAD,than,those,ratio,Prostate,Imaging,Reporting,Data,System,RADS,score,Those,more,likely,experience,after,Independent,preoperative,predicting,odds,confidence,interval,histopathological,specimens,revealed,that,perineural,invasion,PNI,was,identified,Our,results,These,should,be,considered

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