典型文献
Synergistic sulfonamides plus clindamycin as an alternative therapeutic regimen for HIV-associated Toxoplasma encephalitis: a randomized controlled trial
文献摘要：
Background::The preferred therapeutic regimen for Toxoplasma encephalitis (TE) is a combination of pyrimethamine and sulfadiazine, and trimethoprim-sulfamethoxazole (TMP-SMX) plus azithromycin is the widespread alternative therapeutic regimen. The synergistic sulfonamides tablet contains TMP, sulfadiazine, and SMX and hypothetically could be used for TE treatment. This study aimed to compare the efficacy and safety of synergistic sulfonamides plus clindamycin (regimen B) with TMP-SMX plus azithromycin (regimen A) for the treatment of human immunodeficiency virus (HIV) associated TE.Methods::This was an open-labeled, multi-center randomized controlled trial recruited from 11 centers. Each recruited patient was randomly assigned to receive regimen A or regimen B for at least 6 weeks. The overall response was evaluated by assessment of the clinical response of TE-associated clinical features and the radiological response of TE-associated radiological findings. The overall response rate, clinical response rate, radiological response rate, and adverse events were assessed at 2, 6, and 12 weeks. Death events were compared between the two regimens at 6, 12, and 24 weeks.Results::A total of 91 acquired immunodeficiency syndrome (AIDS)/TE patients were included in the final analysis (44 in regimen A
vs. 47 in regimen B). The overall response rate, which refers to the combined clinical and radiological response, was 18.2% (8/44) for regimen A and 21.3 % (10/47) for regimen B at week 6. The results of clinical response showed that, in comparison with regimen A, regimen B may perform better with regards to its effect on the relief of clinical manifestations (50.0% [22/44]
vs. 70.2% [33/47],
P = 0.049). However, no significant differences in radiological response, mortality events, and adverse events were found between the two regimens at week 6.
Conclusions::Synergistic sulfonamides plus clindamycin, as a novel treatment regimen, showed no significantly different efficacy and comparable safety in comparison with the TMP-SMX plus azithromycin regimen. In addition, the regimen containing synergistic sulfonamides may exhibit advantages in terms of clinical symptom alleviation.Trial Registration::ChiCTR.org.cn, ChiCTR1900021195.
文献关键词：
Clindamycin;Efficacy;Human immunodeficiency virus/acquired immunodeficiency syndrome;Safety;Synergistic sulfonamides;Toxoplasma encephalitis
中图分类号：
作者姓名：
Li Yao;Zeng Yanming;Lu Yanqiu;He Xuejiao;Wu Yushan;Zhang Wei;Huang Yanqun;Chen Hui;Chen Yaokai
作者机构：
Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China;School of Biomedical Engineering, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
文献出处：
引用格式：
[1]Li Yao;Zeng Yanming;Lu Yanqiu;He Xuejiao;Wu Yushan;Zhang Wei;Huang Yanqun;Chen Hui;Chen Yaokai-.Synergistic sulfonamides plus clindamycin as an alternative therapeutic regimen for HIV-associated Toxoplasma encephalitis: a randomized controlled trial)[J].中华医学杂志（英文版）,2022(22):2718-2724
A类：
clindamycin,pyrimethamine,hypothetically,ChiCTR1900021195,Clindamycin
B类：
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AB值：
0.393677
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