典型文献
Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants
文献摘要：
A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n=3200)or placebo(n=3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21％(95％CI:53.31-79.69).VE against severe RVGE and RVGE
文献关键词：
中图分类号：
作者姓名：
Zhiwei Wu;Qingliang Li;Yan Liu;Huakun Lv;Zhaojun Mo;Fangjun Li;Qingchuan Yu;Fei Jin;Wei Chen;Yong Zhang;Teng Huang;Xiaosong Hu;Wei Xia;Jiamei Gao;Haisong Zhou;Xuan Bai;Yueyue Liu;Zhenzhen Liang;Zhijun Jiang;Yingping Chen;Jiuwei Zhang;Jialiang Du;Biao Yang;Bo Xing;Yantao Xing;Ben Dong;Qinghai Yang;Chen Shi;Tingdong Yan;Bo Ruan;Haiyun Shi;Xingliang Fan;Dongyang Feng;Weigang Lv;Dong Zhang;Xiangchu Kong;Liuyifan Zhou;Dinghong Que;Hong Chen;Zhongbing Chen;Xiang Guo;Weiwei Zhou;Cong Wu;Qingrong Zhou;Yuqing Liu;Jian Qiao;Ying Wang;Xinguo Li;Kai Duan;Yuliang Zhao;Gelin Xu;Xiaoming Yang
作者机构：
Hebei Center for Disease Control and Prevention,Shijiazhuang,050021,China;National Engineering Technology Research Center for Combined Vaccines,Wuhan Institute of Biological Product Co.,Ltd,Wuhan,430207,China;National Institutes for Food and Drug Control,Beijing,100050,China;Zhejiang Center for Disease Control and Prevention,Hangzhou,310051,China;Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning,530028,China;Hunan Center for Disease Control and Prevention,Changsha,410005,China;Zhengding County Center for Disease Control and Prevention,Shijiazhuang 050800,China;Daming County Center for Disease Control and Prevention,Handan,056900,China;Liucheng County Center for Disease Control and Prevention,Liuzhou,545200,China;Xiangtan County Center for Disease Control and Prevention,Xiangtan,411228,China;Yuhuan County Center for Disease Control and Prevention,Taizhou,317600,China;Yongnian County Center for Disease Control and Prevention,Handan,056000,China;Rongshui Miao Autonomous County Center for Disease Control and Prevention,Liuzhou,545300,China;You County Center for Disease Control and Prevention,Zhuzhou,412315,China;Longyou County Center for Disease Control and Prevention,Quzhou,324400,China;Laishui County Center for Disease Control and Prevention,Baoding 074100,China;Jiangshan County Center for Disease Control and Prevention,Quzhou,324100,China;China National Biotec Group Company Limited,National Engineering Technology Research Center for Combined Vaccines,Wuhan,430207,China
文献出处：
引用格式：
[1]Zhiwei Wu;Qingliang Li;Yan Liu;Huakun Lv;Zhaojun Mo;Fangjun Li;Qingchuan Yu;Fei Jin;Wei Chen;Yong Zhang;Teng Huang;Xiaosong Hu;Wei Xia;Jiamei Gao;Haisong Zhou;Xuan Bai;Yueyue Liu;Zhenzhen Liang;Zhijun Jiang;Yingping Chen;Jiuwei Zhang;Jialiang Du;Biao Yang;Bo Xing;Yantao Xing;Ben Dong;Qinghai Yang;Chen Shi;Tingdong Yan;Bo Ruan;Haiyun Shi;Xingliang Fan;Dongyang Feng;Weigang Lv;Dong Zhang;Xiangchu Kong;Liuyifan Zhou;Dinghong Que;Hong Chen;Zhongbing Chen;Xiang Guo;Weiwei Zhou;Cong Wu;Qingrong Zhou;Yuqing Liu;Jian Qiao;Ying Wang;Xinguo Li;Kai Duan;Yuliang Zhao;Gelin Xu;Xiaoming Yang-.Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants)[J].中国病毒学,2022(05):724-730
A类：
reassortant,RVGE,intussusception
B类：
Efficacy,safety,immunogenicity,hexavalent,rotavirus,vaccine,Chinese,infants,randomized,double,blind,placebo,controlled,multicenter,trial,was,conducted,healthy,assess,efficacy,live,human,bovine,HRV,against,gastroenteritis,total,participants,aged,weeks,were,enrolled,randomly,assigned,either,group,All,subjects,received,three,oral,doses,four,apart,VE,caused,by,serotypes,contained,evaluated,from,days,after,administration,until,end,second,season,severe,hospitalization,natural,infection,any,also,investigated,adverse,events,collected,each,Serious,SAEs,cases,during,entire,study,Our,data,showed,that
AB值：
0.446175
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
