典型文献
Genotype distribution and evolutionary analysis of rotavirus associated with acute diarrhea outpatients in Hubei,China,2013-2016
文献摘要：
Group A human rotaviruses(RVAs)annually cause the deaths of 215,000 infants and young children.To un-derstand the epidemiological characteristics and genetic evolution of RVAs,we performed sentinel surveillance on RVA prevalence in a rotavirus-surveillance network in Hubei,China.From 2013 to 2016,a total of 2007 fecal samples from hospital outpatients with acute gastroenteritis were collected from four cities of Hubei Province.Of the 2007 samples,153(7.62％)were identified positive for RVA by real-time RT-PCR.RVA infection in Hubei mainly occurred in autumn and winter.The highest detection rate of RVA infection was in 1-2 years old of outpatients(16.97％).No significant difference of RVA positive rate was observed between females and males.We performed a phylogenetic analysis of the G/P genotypes based on the partial VP7/VP4 gene sequences of RVAs.G9P[8]was the most predominant strain in all four years but the prevalence of G2P[4]genotype increased rapidly since 2014.We reconstructed the evolutionary time scale of RVAs in Hubei,and found that the evolutionary rates of the G9,G2,P[8],and P[4]genotypes of RVA were 1.069×10-3,1.029×10-3,1.283×10-3 and 1.172 x 10-3 nucleotide substitutions/site/year,respectively.Importantly,using a molecular clock model,we showed that most G9,G2,P[8],and P[4]genotype strains dated from the recent ancestor in 2005,2005,1993,and 2013,respectively.The finding of the distribution of RVAs in infants and young children in Hubei Province will contribute to the understanding of the epidemiological characteristics and genetic evolution of RVAs in China.
文献关键词：
中图分类号：
作者姓名：
Ting Zhang;Jing Li;Yong-Zhong Jiang;Jun-Qiang Xu;Xu-Hua Guan;Li-Qiang Wang;Jie Chen;Yi Liang
作者机构：
Hubei Key Laboratory of Cell Homeostasis,College of Life Sciences,Wuhan University,Wuhan,430072,China;Hubei Provincial Center for Disease Control and Prevention,Wuhan,430079,China
文献出处：
引用格式：
[1]Ting Zhang;Jing Li;Yong-Zhong Jiang;Jun-Qiang Xu;Xu-Hua Guan;Li-Qiang Wang;Jie Chen;Yi Liang-.Genotype distribution and evolutionary analysis of rotavirus associated with acute diarrhea outpatients in Hubei,China,2013-2016)[J].中国病毒学,2022(04):503-512
A类：
rotaviruses,RVAs
B类：
Genotype,distribution,evolutionary,analysis,associated,acute,diarrhea,outpatients,Hubei,China,Group,human,annually,cause,deaths,infants,young,children,To,epidemiological,characteristics,performed,sentinel,surveillance,prevalence,network,From,total,fecal,samples,from,hospital,gastroenteritis,were,collected,four,cities,Province,Of,identified,positive,by,real,infection,mainly,occurred,autumn,winter,highest,detection,was,years,old,No,significant,difference,observed,between,females,We,phylogenetic,genotypes,partial,VP7,VP4,sequences,G9P,most,predominant,G2P,increased,rapidly,since,reconstructed,scale,found,that,rates,nucleotide,substitutions,site,respectively,Importantly,using,molecular,clock,model,showed,strains,dated,recent,ancestor,finding,will,contribute,understanding
AB值：
0.457793
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