典型文献
Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China
文献摘要：
The nationwide COVID-19 epidemic ended in 2020,a few months after its outbreak in Wuhan,China at the end of 2019.Most COVID-19 cases occurred in Hubei Province,with a few local outbreaks in other provinces of China.A few studies have reported the early SARS-CoV-2 epidemics in several large cities or provinces of China.However,information regarding the early epidemics in small and medium-sized cities,where there are still traditionally large families and community culture is more strongly maintained and thus,transmission profiles may differ,is limited.In this study,we characterized 60 newly sequenced SARS-CoV-2 genomes from Anyang as a represen-tative of small and medium-sized Chinese cities,compared them with more than 400 reference genomes from the early outbreak,and studied the SARS-CoV-2 transmission profiles.Genomic epidemiology revealed multiple SARS-CoV-2 introductions in Anyang and a large-scale expansion of the epidemic because of the large family size.Moreover,our study revealed two transmission patterns in a single outbreak,which were attributed to different social activities.We observed the complete dynamic process of single-nucleotide polymorphism development during community transmission and found that intrahost variant analysis was an effective approach to studying cluster infections.In summary,our study provided new SARS-CoV-2 transmission profiles representative of small and medium-sized Chinese cities as well as information on the evolution of SARS-CoV-2 strains during the early COVID-19 epidemic in China.
文献关键词：
中图分类号：
作者姓名：
Yang Li;Hao-Rui Si;Yan Zhua;Nan Xie;Bei Li;Xiang-Ping Zhang;Jun-Feng Han;Hong-Hong Bao;Yong Yang;Kai Zhao;Zi-Yuan Hou;Si-Jia Cheng;Shuan-Hu Zhang;Zheng-Li Shi;Peng Zhou
作者机构：
CAS Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China;Anyang Municipal Center for Disease Control and Prevention,Anyang,455000,China;University of Chinese Academy of Sciences,Beijing,101409,China
文献出处：
引用格式：
[1]Yang Li;Hao-Rui Si;Yan Zhua;Nan Xie;Bei Li;Xiang-Ping Zhang;Jun-Feng Han;Hong-Hong Bao;Yong Yang;Kai Zhao;Zi-Yuan Hou;Si-Jia Cheng;Shuan-Hu Zhang;Zheng-Li Shi;Peng Zhou-.Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China)[J].中国病毒学,2022(02):187-197
A类：
Anyang,introductions,intrahost
B类：
Characteristics,SARS,CoV,transmission,medium,sized,city,communities,during,early,China,nationwide,ended,few,months,after,its,Wuhan,Most,cases,occurred,Hubei,Province,local,outbreaks,other,provinces,studies,have,reported,epidemics,several,large,cities,However,information,regarding,small,where,there,still,traditionally,families,community,culture,more,strongly,maintained,thus,profiles,may,limited,In,this,characterized,newly,sequenced,genomes,from,Chinese,compared,them,than,reference,studied,Genomic,epidemiology,revealed,multiple,scale,expansion,because,family,Moreover,our,two,patterns,single,which,were,attributed,different,social,activities,We,observed,complete,dynamic,process,nucleotide,polymorphism,development,found,that,variant,analysis,was,effective,approach,studying,cluster,infections,summary,provided,representative,well,evolution,strains
AB值：
0.489169
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