典型文献
Prostate Health Index(phi)and its derivatives predict Gleason score upgrading after radical prostatectomy among patients with low-risk prostate cancer
文献摘要：
To analyze the performance of the Prostate Health Index(phi)and its derivatives for predicting Gleason score(GS)upgrading between prostate biopsy and radical prostatectomy(RP)in the Chinese population,an observational,prospective RP cohort consisting of 351 patients from two medical centers was established from January 2017 to September 2020.Pathological reclassification was determined by the Gleason Grade Group(GG).The area under the receiver operating characteristic curve(AUC)and logistic regression(LR)models were used to evaluate the predictive performance of predictors.In clinically low-risk patients with biopsy GG≤2,phi(odds ratio[OR]=1.80,95％confidence interval[95％CI]:1.14-2.82,P=0.01)and its derivative phi density(PHID;OR=2.34,95％CI:1.30-4.20,P=0.005)were significantly associated with upgrading to GG 23 after RP,and the results were confirmed by multivariable analysis.Similar results were observed in patients with biopsy GG of 1 for the prediction of upgrading to RP GG 22.Compared to the base model(AUC=0.59),addition of the phi or PHID could provide additional predictive value for GS upgrading in low-risk patients(AUC=0.69 and 0.71,respectively,both P＜0.05).In conclusion,phi and PHID could predict GS upgrading after RP in clinically low-risk patients.
文献关键词：
中图分类号：
作者姓名：
Jia-Qi Yan;Da Huang;Jing-Yi Huang;Xiao-Hao Ruan;Xiao-Ling Lin;Zu-Jun Fang;Yi Gao;Hao-Wen Jiang;Yi-Shuo Wu;Rong Na;Dan-Feng Xu
作者机构：
Department of Urology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Urology,Huashan Hospital,Fudan University,Shanghai 200040,China
文献出处：
引用格式：
[1]Jia-Qi Yan;Da Huang;Jing-Yi Huang;Xiao-Hao Ruan;Xiao-Ling Lin;Zu-Jun Fang;Yi Gao;Hao-Wen Jiang;Yi-Shuo Wu;Rong Na;Dan-Feng Xu-.Prostate Health Index(phi)and its derivatives predict Gleason score upgrading after radical prostatectomy among patients with low-risk prostate cancer)[J].亚洲男性学杂志（英文版）,2022(04):406-410
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AB值：
0.469226
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