典型文献
A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient mass spectrometry imaging
文献摘要：
The brain is the most advanced organ with various complex structural and functional micro-regions.It is often challenging to understand what and where the molecular events would occur for a given drug treatment in the brain.Herein,a temporo-spatial pharmacometabolomics method was pro-posed based on ambient mass spectrometry imaging and was applied to evaluate the microregional effect of olanzapine(OLZ)on brain tissue and demonstrate its effectiveness in characterizing the microregio-nal pharmacokinetics and pharmacodynamics of OLZ for improved understanding of the molecular mechanism of drugs acting on the microregions of the brain.It accurately and simultaneously illustrated the levels dynamics and microregional distribution of various substances,including exogenous drugs and its metabolites,as well as endogenous functional metabolites from complicated brain tissue.The targeted imaging analysis of the prototype drug and its metabolites presented the absorption,distribu-tion,metabolism,and excretion characteristics of the drug itself.Moreover,the endogenous functional metabolites were identified along with the associated therapeutic and adverse effects of the drug,which can reflect the pharmacodynamics effect on the microregional brain.Therefore,this method is significant in elucidating and understanding the molecular mechanism of central nervous system drugs at the temporo and spatial metabolic level of system biology.
文献关键词：
中图分类号：
作者姓名：
Dan Liu;Jianpeng Huang;Shanshan Gao;Hongtao Jin;Jiuming He
作者机构：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Department of Clinical Pharmacy,First People's Hospital of Huaihua,Huaihua 418000,China;New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug,Beijing 100050,China
文献出处：
引用格式：
[1]Dan Liu;Jianpeng Huang;Shanshan Gao;Hongtao Jin;Jiuming He-.A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient mass spectrometry imaging)[J].药学学报（英文版）,2022(08):3341-3353
A类：
pharmacometabolomics,microregions,microregional,microregio
B类：
temporo,spatial,method,characterize,pharmacokinetics,pharmacodynamics,brain,by,using,ambient,mass,spectrometry,imaging,most,advanced,organ,various,complex,structural,functional,It,often,challenging,what,where,molecular,events,would,occur,given,treatment,Herein,was,posed,applied,evaluate,olanzapine,OLZ,tissue,demonstrate,effectiveness,characterizing,improved,understanding,mechanism,drugs,acting,accurately,simultaneously,illustrated,levels,distribution,substances,including,exogenous,metabolites,well,endogenous,from,complicated,targeted,analysis,prototype,presented,absorption,metabolism,excretion,characteristics,itself,Moreover,were,identified,along,associated,therapeutic,adverse,effects,which,reflect,Therefore,this,significant,elucidating,central,nervous,system,metabolic,biology
AB值：
0.44994
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