典型文献
Metabolomics analysis reveals the renal protective effect of Panax ginseng C.A.Mey in type 1 diabetic rats
文献摘要：
The dry root and rhizome of Panax ginseng C.A.Mey has garnered much interest owing to its medicinal properties against diabetes and cardiovascular diseases.In this study,an ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)-based metabolomics approach was used to illustrate the therapeutic mechan-isms of ginseng extract on the serum and urinary metabolic profiles in streptozotocin-induced type 1 diabetes mellitus(T1DM)rats.Pharmacological and renal parameters in response to the administration of ginseng were also evaluated.In total,16 serum endogenous metabolites and 14 urine endogenous metabolites,including pyruvic acid,indoleacetic acid,and phenylacetylglycine,were identified as potential biomarkers for diabetes.Pathway enrichment and network analysis revealed that the biomarkers modulated by ginseng were primarily involved in phenylalanine and pyruvate metabolism,as well as in arginine biosynthesis.Moreover,the levels of several renal injury-related biomarkers in T1DM rats were significantly restored following treatment with ginseng.The administration of the extract helped maintain tissue structure integrity and ameliorated renal injury.The findings suggest that the regulatory effect of gin-seng extract on T1DM involves metabolic management of diabetic rats,which subsequently attenuates T1DM-induced early renal dys-function.
文献关键词：
中图分类号：
作者姓名：
WANG Xin-Sen;HU Ming-Xin;GUAN Qing-Xiang;MEN Li-Hui;LIU Zhong-Ying
作者机构：
School of Pharmaceutical Sciences,Jilin University,Changchun 130021,China;College of Basic Medical Sciences,Jilin University,Changchun 130021,China
文献出处：
引用格式：
[1]WANG Xin-Sen;HU Ming-Xin;GUAN Qing-Xiang;MEN Li-Hui;LIU Zhong-Ying-.Metabolomics analysis reveals the renal protective effect of Panax ginseng C.A.Mey in type 1 diabetic rats)[J].中国天然药物,2022(05):378-386
A类：
indoleacetic,phenylacetylglycine,seng
B类：
Metabolomics,analysis,reveals,renal,protective,effect,Panax,ginseng,Mey,type,diabetic,rats,dry,root,rhizome,has,garnered,much,interest,its,medicinal,properties,against,diabetes,cardiovascular,diseases,In,this,study,ultra,high,performance,liquid,chromatography,coupled,quadrupole,flight,mass,spectrometry,UHPLC,TOF,metabolomics,approach,was,used,illustrate,therapeutic,mechan,isms,extract,serum,urinary,metabolic,profiles,streptozotocin,induced,mellitus,T1DM,Pharmacological,parameters,response,administration,were,also,evaluated,total,endogenous,metabolites,urine,including,pyruvic,acid,identified,potential,biomarkers,Pathway,enrichment,network,revealed,that,modulated,by,primarily,involved,phenylalanine,pyruvate,metabolism,well,arginine,biosynthesis,Moreover,levels,several,injury,related,significantly,restored,following,treatment,helped,maintain,tissue,structure,integrity,ameliorated,findings,suggest,regulatory,involves,management,which,subsequently,attenuates,early,dys,function
AB值：
0.610778
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
