典型文献
Basophils orchestrate kidney fibrosis
文献摘要：
Basophils,though representing a minor population of leukocytes,have diverse roles in various pathophysiologies.A recent report provides an additional evidence on the pathogenic role of basophils in promoting kidney fibrosis by secreting IL-6 and promoting the Th17 cell differentiation.
Basophils are rare granulocytes that participate in T helper(Th)type 2 immunity,principally through the secretion of interleukins IL-4 and IL-13.Besides their role in the defense against helminth infections,basophils play a major role in the pathogenesis of various allergic inflammatory diseases,autoimmune diseases,and cancer.1 Basophils express a diverse array of receptors,and hence could sense signals from various sources including cytokines,toll-like receptor agonists,and allergens,and subsequently undergo rapid activation and release inflammatory mediators.In addition to IL-4 and IL-13,basophils produce histamine,prostaglandins,leukotrienes,IL-6 and chemokines in response to the stimuli.All these inflammatory mediators are potential contributors of basophil-mediated pathogenesis.
文献关键词：
中图分类号：
作者姓名：
Camille Chauvin;Jagadeesh Bayry
作者机构：
Institut National de la Santé et de la Recherche Médicale,Centre de Recherche des Cordeliers,Sorbonne Université,Université de Paris,Paris,France;Department of Biological Sciences&Engineering,Indian Institute of Technology Palakkad,Palakkad,India
文献出处：
引用格式：
[1]Camille Chauvin;Jagadeesh Bayry-.Basophils orchestrate kidney fibrosis)[J].细胞研究（英文版）,2022(08):713-714
A类：
Basophils,pathophysiologies,basophils,
Basophils,granulocytes,helminth
B类：
orchestrate,kidney,fibrosis,though,representing,minor,population,leukocytes,have,diverse,roles,various,recent,report,provides,additional,evidence,pathogenic,promoting,by,secreting,Th17,cell,differentiation,rare,that,participate,helper,type,immunity,principally,through,secretion,interleukins,Besides,their,defense,against,infections,play,major,pathogenesis,allergic,inflammatory,diseases,autoimmune,cancer,express,array,receptors,hence,could,sense,signals,from,sources,including,cytokines,toll,like,agonists,allergens,subsequently,undergo,rapid,activation,release,mediators,In,produce,histamine,prostaglandins,leukotrienes,chemokines,response,stimuli,All,these,potential,contributors,mediated
AB值：
0.606687
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
