典型文献
Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
文献摘要：
Cytokine release syndrome (CRS) is a major obstacle to the widespread clinical application of chimeric antigen receptor (CAR) T cell therapies. CRS can also be induced by infections (such as SARS-CoV-2), drugs (such as therapeutic antibodies), and some autoimmune diseases. Myeloid-derived macrophages play key roles in the pathogenesis of CRS, and participate in the production and release of the core CRS cytokines, including interleukin (IL)-1, IL-6, and interferon-γ. In this review, we summarize the roles of macrophages in CRS and discuss new developments in macrophage activation and the related mechanisms of cytokine regulation in CRS.
文献关键词：
中图分类号：
作者姓名：
Hanfei Guo;Lei Qian;Jiuwei Cui
作者机构：
Cancer Center,the First Hospital of Jilin University,Changchun 130021,China
文献出处：
引用格式：
[1]Hanfei Guo;Lei Qian;Jiuwei Cui-.Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome)[J].癌症生物学与医学（英文版）,2022(03):333-342
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B类：
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AB值：
0.621979
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