Inflammatory responses,including glial cell activation and peripheral immune cell infiltration,are involved in the pathogenesis of Parkinson's disease (PD).These inflammatory responses appear to be closely related to the release of extracellular vesicles,such as exosomes.However,the relationships among different forms of glial cell activation,synuclein dysregulation,mitochondrial dysfunction,and exosomes are complicated.This review discusses the multiple roles played by exosomes in PD-associated inflammation and concludes that exosomes can transport toxic α-synuclein oligomers to immature neurons and into the extracellular environment,inducing the oligomerization of α-synuclein in normal neurons.Misfolded α-synuclein causes microglia and astrocytes to activate and secrete exosomes.Glial cell-derived exosomes participate in communications between glial cells and neurons,triggering anti-stress and anti-inflammatory responses,in addition to axon growth.The production and release of mitochondrial vesicles and exosomes establish a new mechanism for linking mitochondrial dysfunction to systemic inflammation associated with PD.Given the relevance of exosomes as mediators of neuron-glia communication in neuroinflammation and neuropathogenesis,new targeted treatment strategies are currently being developed that use these types of extracellular vesicles as drug carriers.Exosome-mediated inflammation may be a promising target for intervention in PD patients.

Ke-Lu Li;Hong-Yan Huang;Hui Ren;Xing-Long Yang

Department of Geriatric Neurology,First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan Province,China;Department of Neurology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China

中国神经再生研究（英文版）

[1]Ke-Lu Li;Hong-Yan Huang;Hui Ren;Xing-Long Yang-.Role of exosomes in the pathogenesis of inflammation in Parkinson's disease)[J].中国神经再生研究（英文版）,2022(09):1898-1906

Misfolded,neuropathogenesis

Role,exosomes,Parkinson,disease,Inflammatory,responses,including,glial,activation,peripheral,immune,infiltration,are,involved,These,inflammatory,appear,closely,related,release,extracellular,vesicles,such,However,relationships,among,different,forms,synuclein,dysregulation,mitochondrial,dysfunction,complicated,This,review,discusses,multiple,roles,played,by,associated,concludes,that,can,transport,toxic,oligomers,immature,neurons,into,environment,inducing,oligomerization,normal,causes,microglia,astrocytes,activate,secrete,Glial,derived,participate,communications,between,cells,triggering,anti,stress,addition,axon,growth,production,establish,new,mechanism,linking,systemic,Given,relevance,mediators,neuroinflammation,targeted,treatment,strategies,currently,being,developed,these,types,drug,carriers,Exosome,mediated,may,promising,intervention,patients

0.547059