典型文献
The"mitochondrial stress responses":the"Dr.Jekyll and Mr.Hyde"of neuronal disorders
文献摘要：
Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions,such as oxidative and metabolic stress,protein folding or import defects,and mitochondrial DNA alteration.Cells engage in different coordinated responses to safeguard mitochondrial homeostasis.In this review,we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions,keep them under control and rescue the physiological condition of nervous cells.In the sections to come,particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion,mitophagy,mitochondrial unfolding protein response,and apoptosis impact human neuronal diseases.Finally,we will discuss the relevance of the new concept:the"mito-inflammation",a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases,including neuronal disorders.
文献关键词：
中图分类号：
作者姓名：
Simone Patergnani;Giampaolo Morciano;Marianna Carinci;Sara Leo;Paolo Pinton;Alessandro Rimessi
作者机构：
Department of Medical Sciences,Section of Experimental Medicine,Laboratory for Technologies of Advanced Therapies,University of Ferrara,Ferrara,Italy;Center of Research for Innovative Therapies in Cystic Fibrosis,University of Ferrara,Ferrara,Italy
文献出处：
引用格式：
[1]Simone Patergnani;Giampaolo Morciano;Marianna Carinci;Sara Leo;Paolo Pinton;Alessandro Rimessi-.The"mitochondrial stress responses":the"Dr.Jekyll and Mr.Hyde"of neuronal disorders)[J].中国神经再生研究（英文版）,2022(12):2563-2575
A类：
Jekyll,Hyde,hyperfusion
B类：
mitochondrial,stress,responses,Dr,Mr,neuronal,disorders,Neuronal,are,associated,profound,loss,functions,caused,by,various,conditions,such,oxidative,metabolic,protein,import,defects,alteration,Cells,engage,different,coordinated,safeguard,homeostasis,In,this,review,we,will,explore,contribution,that,activated,organelle,perceive,these,dangerous,keep,them,under,control,rescue,physiological,nervous,cells,sections,come,particular,attention,be,dedicated,analyzing,how,compensatory,mitophagy,unfolding,apoptosis,impact,human,diseases,Finally,discuss,relevance,new,concept,inflammation,mediated,inflammatory,recently,cover,relevant,role,pathogenesis,diverse,related,including
AB值：
0.613391
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
