典型文献
Heterogeneity of neutrophils in cancer: one size does not fit all
文献摘要：
Neutrophils play an essential role in the defense against bacterial infections and orchestrate both the innate and adaptive immune responses. With their abundant numbers, diverse function and short life span, these cells are at the forefront of immune responses, and have gained attention in recent years because of their presence in tumor sites. Neutrophil involvement pertains to tumor cells' ability to construct a suitable tumor microenvironment (TME) that accelerates their own growth and malignancy, by facilitating their interaction with surrounding cells through the circulatory and lymphatic systems, thereby influencing tumor development and progression. Studies have indicated both pro- and anti-tumor properties of infiltrating neutrophils. The TME can exploit neutrophil function, recruitment, and even production, thus resulting in pro-tumor properties of neutrophils, including promotion of genetic instability, tumor cell proliferation, angiogenesis and suppression of anti-tumor or inflammatory response. In contrast, neutrophils can mediate anti-tumor resistance by direct cytotoxicity to the tumor cells or by facilitating anti-tumor functions via crosstalk with T cells. Here, we summarize current knowledge regarding the effects of neutrophil heterogeneity under homeostatic and tumor conditions, including neutrophil phenotype and function, in cancer biology.
文献关键词：
中图分类号：
作者姓名：
Song Chen;Qingyu Zhang;Lisha Lu;Chunhui Xu;Jiajia Li;Jiali Zha;Fengxia Ma;Hongbo R.Luo;Alan Y.Hsu
作者机构：
State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China;Department of Pathology,Harvard Medical School,Boston,MA 02115,USA;Department of Laboratory Medicine,The Stem Cell Program,Boston Children's Hospital,Boston,MA 02115,USA;Dana-Farber/Harvard Cancer Center,Boston,MA 02115,USA
文献出处：
引用格式：
[1]Song Chen;Qingyu Zhang;Lisha Lu;Chunhui Xu;Jiajia Li;Jiali Zha;Fengxia Ma;Hongbo R.Luo;Alan Y.Hsu-.Heterogeneity of neutrophils in cancer: one size does not fit all)[J].癌症生物学与医学（英文版）,2022(12):1629-1648
A类：
B类：
Heterogeneity,neutrophils,cancer,one,size,does,fit,all,Neutrophils,play,essential,role,defense,against,bacterial,infections,orchestrate,both,innate,adaptive,immune,responses,With,their,abundant,numbers,diverse,short,span,these,cells,are,forefront,have,gained,attention,recent,years,because,presence,tumor,sites,involvement,pertains,construct,suitable,microenvironment,TME,that,accelerates,own,growth,malignancy,facilitating,interaction,surrounding,through,circulatory,lymphatic,systems,thereby,influencing,development,progression,Studies,indicated,anti,properties,infiltrating,exploit,recruitment,even,production,thus,resulting,including,promotion,genetic,instability,proliferation,angiogenesis,suppression,inflammatory,In,contrast,mediate,resistance,direct,cytotoxicity,functions,via,crosstalk,Here,we,summarize,current,knowledge,regarding,effects,heterogeneity,under,homeostatic,conditions,phenotype,biology
AB值：
0.630658
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
