典型文献
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly
文献摘要：
Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis.However,the role of microtubule (MT) post-translational modifications in nuclear shape regulation and cilium disassembly has not been explored.Here we identified a novel regulator of the tubulin polyglutamylase complex (TPGC),C11ORF49/CSTPP1,that regulates cytoskeletal organization,nuclear shape,and cilium disassembly.Mechanistically,loss of C11ORF49/CSTPP1 impacts the assembly and stability of the TPGC,which modulates long-chain polyglutamylation levels on microtubules (MTs) and thereby balances the binding of MT-associated proteins and actin nucleators.As a result,loss of TPGC leads to aberrant,enhanced assembly of MTs that penetrate the nucleus,which in turn leads to defects in nuclear shape,and disorganization of cytoplasmic actin that disrupts the YAP/TAZ pathway and cilium disassembly.Further,we showed that C11ORF49/CSTPP1-TPGC plays mechanistically distinct roles in the regulation of nuclear shape and cilium disassembly.Remarkably,disruption of C11ORF49/CSTPP1-TPGC also leads to developmental defects in vivo.Our findings point to an unanticipated nexus that links tubulin polyglutamylation with nuclear shape and ciliogenesis.
文献关键词：
中图分类号：
作者姓名：
Lei Wang;Sharad C.Paudyal;Yuchen Kang;Mikito Owa;Feng-Xia Liang;Alexander Spektor;Holger Knaut;Irma Sánchez;Brian D.Dynlacht
作者机构：
Department of Pathology,New York University Cancer Institute,New York University School of Medicine,New York,NY,USA;Department of Radiation Oncology,Dana-Farber Cancer Institute,Brigham and Women's Hospital,Harvard Medical School,Boston,MA,USA;Microscopy Laboratory,Division of Advanced Research Technologies,NYU Langone Health,New York,NY,USA;Skirball Institute of Biomolecular Medicine,New York University School of Medicine,New York,NY,USA
文献出处：
引用格式：
[1]Lei Wang;Sharad C.Paudyal;Yuchen Kang;Mikito Owa;Feng-Xia Liang;Alexander Spektor;Holger Knaut;Irma Sánchez;Brian D.Dynlacht-.Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly)[J].细胞研究（英文版）,2022(02):190-209
A类：
polyglutamylation,Cytoskeletal,polyglutamylase,TPGC,C11ORF49,CSTPP1,nucleators,disorganization
B类：
Regulators,tubulin,control,nuclear,shape,cilium,disassembly,balancing,actin,networks,important,regulating,morphology,ciliogenesis,However,post,translational,modifications,regulation,has,not,been,explored,Here,identified,novel,regulator,complex,that,regulates,cytoskeletal,Mechanistically,loss,impacts,stability,which,modulates,long,chain,levels,microtubules,MTs,thereby,balances,binding,associated,proteins,result,leads,aberrant,enhanced,penetrate,nucleus,turn,defects,cytoplasmic,disrupts,YAP,TAZ,pathway,Further,showed,plays,mechanistically,distinct,roles,Remarkably,disruption,also,developmental,vivo,Our,findings,point,unanticipated,nexus,links
AB值：
0.42248
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