典型文献
Nuclear cGAS:sequestration and beyond
文献摘要：
The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type Ⅰ interferon and inflammation responses via the STING-dependent signaling pathway.In the past several years,a growing body of evidence has revealed that cGAS is also local-ized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes,DNA replication forks,the double-stranded breaks,and cen-tromeres,suggesting that cGAS may have other func-tions in addition to its role in DNA sensing.However,while the innate immune function of cGAS is well established,the non-canonical nuclear function of cGAS remains poorly understood.Here,we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function,beyond its well-established role in dsDNA sensing and innate immune response.
文献关键词：
中图分类号：
作者姓名：
Juli Bai;Feng Liu
作者机构：
Departments of Pharmacology,University of Texas Health at San Antonio,San Antonio,TX,USA;National Clinical Research Center for Metabolic Diseases,Metabolic Syndrome Research Center,Key Laboratory of Diabetes Immunology,Ministry of Education,and Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,Changsha 410011,China
文献出处：
引用格式：
[1]Juli Bai;Feng Liu-.Nuclear cGAS:sequestration and beyond)[J].蛋白质与细胞,2022(02):90-101
A类：
nucleosomes,forks,tromeres
B类：
Nuclear,cGAS,sequestration,beyond,cyclic,GMP,cGAMP,synthase,been,identified,cytosolic,double,stranded,sensor,that,plays,pivotal,type,interferon,inflammation,responses,via,STING,dependent,signaling,pathway,In,past,several,years,growing,body,evidence,revealed,also,local,ized,nucleus,where,associated,distinct,nuclear,substructures,such,replication,breaks,cen,suggesting,may,have,other,addition,its,sensing,However,while,innate,immune,function,well,established,canonical,remains,poorly,understood,Here,review,our,current,understanding,complex,nature,point,open,questions,novel,roles,mechanisms,action,this,protein,key,regulator,cell,dsDNA
AB值：
0.582014
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
