典型文献
A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells
文献摘要：
Zika virus(ZIKV)infection can cause severe neurological diseases including neonatal microcephaly and Guillain-Barre syndrome.Long noncoding RNAs(lncRNAs)are the by-products of the transcription process,which are considered to affect viral infection.However,it remains largely unexplored whether host lncRNAs play a role in ZIKV infection.Here,we identified a group of human lncRNAs that were up-regulated upon ZIKV infection and were dependent on the type Ⅰ interferon(IFN)signaling.Overexpression of lncRNA ZAP-IT1 leads to an impairment of ZIKV infection.Correspondently,deficiency of ZAP-IT1 led to an enhancement of ZIKV infection.We further confirmed that ZAP-IT1,an intronic lncRNA with total 551 nt in length,is mainly located in the nuclear upon ZIKV infection.Knockout of ZAP-IT1 also led to the increase of dengue virus(DENV),Japanese encephalitis virus(JEV),or vesicular stomatitis virus(VSV)infection.Mechanically,we found that the antiviral effect of ZAP-IT1 was independent of the type Ⅰ IFN signaling pathway.Therefore,our data unveiled that host lncRNA ZAP-IT1 induced by the type Ⅰ IFN signaling,showed robust restriction on ZIKV infection,and even on DENV,JEV,and VSV infection,which may benefit the development of antiviral therapeutics.
文献关键词：
中图分类号：
作者姓名：
Yanxia Huang;Yu Su;Li Shen;Zhiting Huo;Cancan Chen;Tao Sun;Xu Tian;Ning Li;Chao Yang
作者机构：
Department of Neurosurgery,First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China;Department of Microbiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,510080,China;Department of Immunology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,510080,China;Department of Pathology,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,510080,China
文献出处：
引用格式：
[1]Yanxia Huang;Yu Su;Li Shen;Zhiting Huo;Cancan Chen;Tao Sun;Xu Tian;Ning Li;Chao Yang-.A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells)[J].中国病毒学,2022(06):904-912
A类：
IFNbeta,Correspondently
B类：
novel,induced,long,ZAP,IT1,interrupts,Zika,virus,replication,A549,cells,ZIKV,infection,can,cause,severe,neurological,diseases,including,neonatal,microcephaly,Guillain,Barre,syndrome,Long,noncoding,lncRNAs,are,by,products,transcription,process,which,considered,affect,However,remains,largely,unexplored,whether,host,play,role,Here,identified,group,human,that,were,regulated,upon,type,interferon,signaling,Overexpression,leads,impairment,deficiency,enhancement,We,further,confirmed,intronic,total,length,mainly,located,nuclear,Knockout,also,increase,dengue,DENV,Japanese,encephalitis,JEV,vesicular,stomatitis,VSV,Mechanically,found,antiviral,effect,was,independent,pathway,Therefore,our,data,unveiled,showed,robust,restriction,even,may,benefit,development,therapeutics
AB值：
0.502056
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
