典型文献
Tongmai Yangxin Pill combined with metoprolol or metoprolol alone for the treatment of symptomatic premature ventricular complex: a multicenter, randomized, parallel-controlled clinical study
文献摘要：
OBJECTIVE To investigate the effects of Tongmai Yangxin Pill (TMYXP) combined with metoprolol tartrate or metoprolol alone for the treatment of premature ventricular complex (PVC) in patients with symptomatic frequent PVC. METHODS A total of 584 patients with symptomatic frequent PVC were randomly assigned (in a 1:1 ratio) into two groups:study group [n = 292, TMYXP (40 pills twice/day, orally) combined with metoprolol tartrate (25 mg twice/day, orally)] and con-trol group [n = 292, metoprolol tartrate (25 mg twice/day, orally) plus placebo pill (40 pills twice/day, orally)]. The total treatment period was eight weeks. RESULTS After eight weeks of treatment, the total effective rate of reduction of PVC in the study group and the control group were 76.4％ and 51.4％, respectively (P < 0.001). TMYXP combined with metoprolol tartrate demonstrated a significantly greater reduction of the frequency of PVCs compared with the metoprolol tartrate alone (?4537 times/24 h vs. ?3013 times/24 h, P < 0.001). The study group also showed a better result compared with the control group with respect to PVC related symptoms. In terms of New York Heart Association classification improvement, the total effective rates were 21.9％ in the study group and 12.4％ in the control group (P < 0.05). Both the study group and the control group exhibited improvements in echocardiographic indexes. Left ventricular ejection fraction was significantly improved in the study group compared with the control group (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups. CONCLUSIONS Compared with metoprolol tartrate alone, TMYXP combined with metoprolol tartrate could more effectively reduce the frequency of PVC and alleviated PVC related symptoms, and improve cardiac function in patients with symptomatic PVC.
文献关键词：
中图分类号：
作者姓名：
Li-Jun LIU;Guo-Hua ZHU;Hong-Yu LUO;Xi-Peng SUN;Jing LI;Qi HUA
作者机构：
Department of Cardiology,Xuanwu Hospital Capital Medical University,Beijing,China;Department of Geriatrics,Xuanwu Hospital Capital Medical University,Beijing,China
文献出处：
引用格式：
[1]Li-Jun LIU;Guo-Hua ZHU;Hong-Yu LUO;Xi-Peng SUN;Jing LI;Qi HUA-.Tongmai Yangxin Pill combined with metoprolol or metoprolol alone for the treatment of symptomatic premature ventricular complex: a multicenter, randomized, parallel-controlled clinical study)[J].老年心脏病学杂志（英文版）,2022(04):284-291
A类：
Tongmai,Yangxin,TMYXP
B类：
Pill,combined,metoprolol,alone,treatment,symptomatic,premature,ventricular,complex,multicenter,randomized,parallel,controlled,clinical,study,OBJECTIVE,investigate,effects,tartrate,patients,frequent,METHODS,total,were,randomly,assigned,ratio,into,two,groups,pills,twice,day,orally,plus,placebo,period,was,eight,weeks,RESULTS,After,reduction,respectively,demonstrated,significantly,greater,frequency,PVCs,compared,times,also,showed,better,result,related,symptoms,In,terms,New,York,Heart,Association,classification,rates,Both,exhibited,improvements,echocardiographic,indexes,Left,ejection,fraction,improved,There,no,difference,incidence,adverse,events,between,CONCLUSIONS,Compared,could,more,effectively,reduce,alleviated,cardiac,function
AB值：
0.371768
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