OBJECTIVE:To investigate the effect of the decoction of Fuzheng Jiedu Xiaoji formula(扶正E解毒消积方,FJXF)plus chemoembolization(TACE)on primary liver cancer(PLC)in patients,and study the underlying mechanism.METHODS:Patients with PLC who met the inclusion criteria were randomized into case group and control group.The case group was treated with FJXF combined with TACE.The control group was treated with TACE alone.The short-term clinical effect was evaluated;liver biochemistry,liver function index and multidrug resistance-associated indicators were detected.RESULTS:FJXF combined with TACE in the case group significantly increased the disease control rate than TACE alone in the control group(83.3％vs 61.1％).There was a reduction in the serum alpha-fetoprotein at 8 weeks after treatment in each group,while no difference between the two groups.The same trend can be observed for transaminase and direct bilirubin in both groups.In the case group,it showed a significant increase for albumin at 8 weeks after treatment,while no change in the control group.Multidrug resistance-associated indicators for multidrug resistance protein 1 and p-glycoprotein were upregulated in the case group but remained stable in the control group.CONCLUSIONS:FJXF combined TACE had a better short-term effect than TACE alone in patients with PLC.The potential mechanism was probably associated with alleviated multidrug resistance induced by FJXF.Additionally,FJXF didn't increase the risk of liver damage in the combined therapy.

WU Tong;YANG Zhiyun;YANG Yuying;JIANG Yuyong;MENG Peipei;LIU Huimin;TIAN Yehong;ZHANG Qiaoli

Department of Integrated Traditional Chinese and Western Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Acupuncture and Minimally Invasive Oncology,The Third Affiliated Hospital,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Acupuncture and Moxibustion,Shaanxi University of Chinese Medicine,Shaanxi 712046,China

中医杂志（英文版）

[1]WU Tong;YANG Zhiyun;YANG Yuying;JIANG Yuyong;MENG Peipei;LIU Huimin;TIAN Yehong;ZHANG Qiaoli-.Effect of decoction of Fuzheng Jiedu Xiaoji formula(扶正解毒消积方)plus chemoembolization on primary liver cancer in patients)[J].中医杂志（英文版）,2022(03):446-450

Xiaoji,FJXF

Effect,decoction,Fuzheng,Jiedu,formula,扶正解毒消积方,plus,chemoembolization,primary,liver,cancer,patients,OBJECTIVE,To,investigate,effect,TACE,PLC,study,underlying,mechanism,METHODS,Patients,who,met,inclusion,criteria,were,randomized,into,case,control,was,treated,combined,alone,short,term,clinical,evaluated,biochemistry,function,multidrug,resistance,associated,indicators,detected,RESULTS,significantly,increased,disease,rate,than,There,reduction,serum,alpha,fetoprotein,weeks,after,treatment,each,while,no,difference,between,two,groups,same,trend,observed,transaminase,direct,bilirubin,both,In,showed,albumin,change,Multidrug,glycoprotein,upregulated,but,remained,stable,CONCLUSIONS,had,better,potential,probably,alleviated,induced,by,Additionally,didn,risk,damage,therapy

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