Dechloranes are a group of halogenated flame retardants with a basic bicyclo[2.2.1]heptene,including Dechlorane Plus (DP),Dechlorane 602 (Dec 602),Dechlorane 603 (Dec 603) and Dechlorane 604 (Dec 604).A few epidemiological investigations and animal experiments have shown that DP exhibited thyroid-interfering effects.In the present study,we investi-gated whether DP and three other dechloranes could interfere the thyroid function through thyroid hormone receptors (TRs,TRα and TRβ) signaling pathways.The binding affinities of the four dechloranes to the two TRs were determined by fluorescence competitive binding assay.It was found that all the four dechloranes could bind with the two TRs.The relative potency (RP) values ranged from nd (not detectable) to 0.0667.Between the two TRs,dechlo-ranes were more inclined to bind with TRβ,which implies that the thyroid interference effect of dechloranes may have selectivity in different tissues and organs.TRs-mediated luciferase reporter gene assay and T-screen assay showed that all the four dechloranes ex-hibited antagonistic activity to TRs in the cells.Taken together,our results demonstrated that dechloranes might interfere with thyroid function by binding with TRs and acting as TR antagonists.The health risk of highly exposed human populations should be of serious concern because of the high hazard quotient calculated from our cell assay results.

Jianqiao Zhu;Lixia Zhao;Lianghong Guo

State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;College of Resources and Environment,University of Chinese Academy of Sciences,Beijing 100049,China;Institute of Environmental and Health Sciences,China Jiliang University,Hangzhou 310018,China;Institute of Environment and Health,Jianghan University,Wuhan 430056,China

环境科学学报（英文版）

[1]Jianqiao Zhu;Lixia Zhao;Lianghong Guo-.Dechloranes exhibit binding potency and activity to thyroid hormone receptors)[J].环境科学学报（英文版）,2022(02):16-24

Dechloranes,heptene,Dechlorane,dechloranes,dechlo,ranes

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