典型文献
Tuning the Stability of the Polyplex Nanovesicles of Oligonucleotides via a Zinc(Ⅱ)-Coordinative Strategy
文献摘要：
Oligonucleotide therapeutics have great potential to target the currently undruggable genes and to generate entirely new therapeutic paradigms in multiple types of disease,thus having attracted much attention in recent years.However,their applications are greatly hindered by a lack of safe and efficient oligonucleotide-delivery vectors.Polyplex nanovesicles formed from oligonucleotides and the cationic block have shown exceptional features for the delivery of therapeutic oligonucleotides and other biopharmaceuticals.Nevertheless,these polyplex nanovesicles are deeply fraught with difficulty in tolerating physiological ionic strength.Inspired by the high binding ability between the dipicolylamine(DPA)/zinc(Ⅱ)complex and the phosphodiester moieties of oligonucleotides,herein,we designed a coordinative cationic block to solve the intrinsic stability dilemma.Moreover,we found the stability of the resulted polyplex nanovesicles could be easily tuned by the content of coordinated zinc ions.In vitro cellular studies implied that the prepared zinc(Ⅱ)-coordinative polyplex nanovesicles preferred to retain in the lysosomes upon internalization,making them ideal delivery candidates for the lysosome-targeting oligonucleotide therapeutics.
文献关键词：
中图分类号：
作者姓名：
Quan Zhou;Xiang Li;Jia-Jia Xiang;You-Qing Shen
作者机构：
Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;Department of Cell Biology,School of Basic Medical Sciences,Zhejiang University,Hangzhou 310058,China;The Forth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu322000,China;Hangzhou Global Scientific and Technological Innovation Center,Hangzhou 311215,China
文献出处：
引用格式：
[1]Quan Zhou;Xiang Li;Jia-Jia Xiang;You-Qing Shen-.Tuning the Stability of the Polyplex Nanovesicles of Oligonucleotides via a Zinc(Ⅱ)-Coordinative Strategy)[J].高分子科学（英文版）,2022(09):1034-1042
A类：
Polyplex,Nanovesicles,Oligonucleotides,Coordinative,Oligonucleotide,tolerating,dipicolylamine,phosphodiester,coordinative
B类：
Tuning,Stability,via,Zinc,Strategy,therapeutics,have,potential,currently,undruggable,genes,generate,entirely,new,paradigms,multiple,types,disease,thus,having,attracted,much,attention,recent,years,However,their,applications,greatly,hindered,by,lack,safe,efficient,delivery,vectors,nanovesicles,formed,from,oligonucleotides,cationic,block,shown,exceptional,features,other,biopharmaceuticals,Nevertheless,these,polyplex,deeply,fraught,difficulty,physiological,strength,Inspired,high,binding,between,DPA,zinc,complex,moieties,herein,designed,solve,intrinsic,stability,dilemma,Moreover,found,resulted,could,easily,tuned,content,coordinated,vitro,cellular,studies,implied,that,prepared,preferred,retain,lysosomes,upon,internalization,making,them,ideal,candidates,targeting
AB值：
0.553978
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