典型文献
Clickable,Oxidation-Responsive and Enzyme-Degradable Polypeptide:Synthesis,Characterization and Side Chain Modification
文献摘要：
Modifications at polypeptide side chains have been found to affect conformational and properties,which is a vital strategy to prepare functional polypeptides.This contribution describes the synthesis of homo and co-polypeptides containing unsaturated bonds and thioether moieties,poly(S-allylcysteine)(PAC).The pendant vinyl groups provide an active binding site which are able to be further modified with cysteine by thiol-ene click reaction.The sulfoxide from thioether oxidation bestows the polypeptide water solubility and enzymatic catalytic sites.The self-assembly micelles of PEG-b-PAC are ruptured along with oxidation to release the Nile red payloads.Moreover,poly(S-allyl-cysteine sulfoxide),aka.polyalliin,is the oxidation product of PAC which undergoes side chain cleavage catalyzed by alliinase enzyme.The polypeptides are biocompati-ble as confirmed by cell viability assays and may find applications in drug delivery,biosensing and nanoreactor.
文献关键词：
中图分类号：
作者姓名：
Yan-Zhi Lu;An-Qi Gu;Tian-Lun Shen;Ji-Hong Sun;Jun Ling
作者机构：
Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;Department of Radiology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China
文献出处：
引用格式：
[1]Yan-Zhi Lu;An-Qi Gu;Tian-Lun Shen;Ji-Hong Sun;Jun Ling-.Clickable,Oxidation-Responsive and Enzyme-Degradable Polypeptide:Synthesis,Characterization and Side Chain Modification)[J].高分子科学（英文版）,2022(11):1360-1368
A类：
Clickable,Polypeptide,thioether,allylcysteine,bestows,polyalliin,alliinase,biocompati
B类：
Oxidation,Responsive,Enzyme,Degradable,Synthesis,Characterization,Side,Chain,Modifications,side,chains,have,been,found,affect,conformational,properties,which,vital,strategy,prepare,functional,polypeptides,This,contribution,describes,synthesis,homo,containing,unsaturated,bonds,moieties,PAC,pendant,vinyl,groups,provide,active,binding,further,modified,by,thiol,ene,click,reaction,sulfoxide,from,oxidation,water,solubility,enzymatic,catalytic,sites,self,assembly,micelles,PEG,ruptured,along,release,Nile,payloads,Moreover,aka,product,undergoes,cleavage,catalyzed,enzyme,confirmed,viability,assays,may,find,applications,drug,delivery,biosensing,nanoreactor
AB值：
0.581883
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
