典型文献
Associations between the Serum Zinc Levels and Digestive Tract Tumors:A Meta-Analysis
文献摘要：
Background The incidence and mortality rates of digestive tract tumors are among the top ten worldwide.Notably,studies have shown that zinc may be significantly related to digestive tract tumors.This meta-analysis was conducted to explore whether the serum zinc level of patients is associated with gastrointestinal cancer.Methods We systematically searched PUBMED,the Cochrane Library,the Web of Science and EMBASE from their start dates up to October 2022 for studies on the association between the serum zinc concentration and digestive tract tumors.The I2 statistic was used to assess the heterogeneity.A sensitivity analysis,subgroup analysis and meta-regression analysis were also used to analyze heterogeneity.Moreover,Begg's and Egger's tests were adopted to assess potential publication bias.Results In total,we identified 24 eligible studies with 1,499 total participants with digestive tract tumors and 6,039 participants without tumors.The average serum zinc concentration in patients with digestive tract tumors was lower than that in the control group(SMD=-0.98,95％CI:-1.29～-0.66,I2:94.1％,P＜0.001).Specifically,the serum zinc concentration of patients with esophageal cancer(SMD=-2.08,95％CI:-2.89～-1.26,I2:92.9％,P＜0.001),gastric cancer(SMD=-0.74,95％CI:-1.16～-0.33,I2:92.1％,P＜0.001),and colorectal cancer(SMD=-0.85,95％CI:-1.51～-0.19,I2:95.9％P＜0.05)were significantly different from the controls.Conclusion Our review showed that the serum zinc concentration in patients with digestive tract tumors was lower than that in patients without tumors,and further studies are needed to explore how zinc affects the occurrence and development of digestive tract tumors.
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作者姓名：
You Wu;Min Li;Ai Ling Li;Shan Bin Fu;Zhang Ze Yu;Chen Li;Pei Ping Ni;Min Wang
作者机构：
Department of Clinical Nutrition,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan China;Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou,Luzhou 646000,Sichuan China;Department of the School of Public Health of Southwest Medical University,Luzhou 646000,China;Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan China
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引用格式：
[1]You Wu;Min Li;Ai Ling Li;Shan Bin Fu;Zhang Ze Yu;Chen Li;Pei Ping Ni;Min Wang-.Associations between the Serum Zinc Levels and Digestive Tract Tumors:A Meta-Analysis)[J].肿瘤营养学杂志（英文）,2022(04):181-191
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