Background:Although brain-derived neurotrophic factor(BDNF)has been identified as a molecular biomarker of the neurophysiological effects induced by exercise,the acute effects of high-intensity exercise(HIE)on BDNF levels are inconclusive.This study aims to estimate the immedi-ate effects of HIE on BDNF levels in healthy young adults.Methods:A systematic search was conducted in the MEDLINE,Scopus,Cochrane CENTRAL,and SPORTDiscuss databases up to December 2020.Randomized controlled trials(RCTs)and non-RCTs reporting pre-post changes in serum or plasma BDNF after an acute intervention of HIE compared to a control condition were included.Pooled effect sizes(p-ESs)and 95％confidence intervals(95％CIs)were calculated for RCTs using a random effects model with Stata/SE(Version 15.0;StataCorp.,College Station,TX,USA).The Preferred Reporting Items for Sys-tematic Reviews and Meta-Analyses guidelines were followed.PROPERO registration number:CRD42020221047.Results:A total of 22 studies with 552 individuals(age range:20-31 years;59.1％male)were included.The meta-analysis included 10 RCTs that reported valid outcome data.Higher BDNF levels were observed when HIE interventions were compared with non-exercise(p-ES=0.55,95％CI:0.12-0.98;I2=25.7％;n=4 studies)and light-intensity exercise(p-ES=0.78,95％CI:0.15-1.40;I2=52.4％;n=3 studies)but not moderate-intensity exercise(p-ES=0.93,95％CI:-0.16 to 2.02;I2=88.5％;n=4 studies)conditions.Conclusion:In comparison to non-exercise or light-intensity exercises,an immediate increase in BDNF levels may occur when young adults per-form HIE.Given the benefits obtained maximizing circulating BDNF when performing HIE and its potential effects on brain health,our findings suggest that HIE could be recommended by clinicians as a useful exercise strategy to healthy adults.

Rubén Fernández-Rodríguez;Celia álvarez-Bueno;Isabel A.Martínez-Ortega;Vicente Martínez-Vizcaíno;Arthur Eumann Mesas;Blanca Notario-Pacheco

Health and Social Research Center,Universidad de Castilla-La Mancha,Cuenca 16071,Spain;Universidad Politécnica y Artística del Paraguay,Asunción 2024,Paraguay;Faculty of Medicine,Universidad Autónoma de Chile,Talca 3460000,Chile;Postgraduate Program in Public Health,Universidad Estadual de Londrina,Londrina 86051-990,Brazil

运动与健康科学（英文）

[1]Rubén Fernández-Rodríguez;Celia álvarez-Bueno;Isabel A.Martínez-Ortega;Vicente Martínez-Vizcaíno;Arthur Eumann Mesas;Blanca Notario-Pacheco-.Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults:A systematic review and meta-analysis)[J].运动与健康科学（英文）,2022(03):367-375

SPORTDiscuss,StataCorp,PROPERO,CRD42020221047

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