Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group(120 cases)and a treatment group(121 cases)using a central block randomization from June 2015 to May 2018.The control group was treated with Western medicines alone including pidotimod dispersible tablets,vitamin B compound tablets,and compound cod liver oil-zinc oxide ointment.The treatment group was treated with ZMTM every 2 days combined with Western medicines.The two groups received continuous intervention for 30 days.The primary outcome was Psoriasis Area and Severity Index(PASI),and the secondary outcomes included Itch Rating Scale,Dermatology Quality of Life Index(DLQI),Hamilton Anxiety Rating Scale(HAMA),as well as PASI response rate.Meanwhile,adverse events were evaluated during the whole clinical trial.Follow-up was carried out 30 days after treatment.Results:There were 5 cases of shedding in this trial.In intention-to-treat analysis,236 cases were included and each group contained 118 cases.On the 30th and 60th days,PASI scores of patients in each group were significantly lower than that at baseline(P＜0.01)and the PASI score reduction of the treatment group was greater than that of the control group(P＜0.01).Itch Rating Scale,DLQI,and HAMA scale were decreased in both groups after treatment,and the treatment group showed a better therapeutic effect(P＜0.01).The response rates of PASI 50 and 75 were significantly higher than those in the control group[81.4％(96/118),43.2％(51/118)vs.41.5％(49/118),11.0％(13/118),respectively,P＜0.05].During follow-up,the improvements in scores of PASI,Itch Rating Scale,DLQI,and HAMA of the treatment group were significantly greater than those of the control group(P＜0.01).The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group,respectively(both P＜0.05).No obvious adverse reaction was found in either group.Conclusion:ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction.(Trial Registration No.ChiCTR-IOR-16008159)

PANG Yu-zhou;TANG Jing;ZHANG Qing-huai;LIANG Feng-zhen;FANG Gang;ZHAO Chen;SHANG Hong-cai;WANG Li-ying;WANG Yan-ping

School of Zhuang Medicine,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Zhuang Medicine Acupuncture,Guangxi International Hospital of Zhuang Medicine Affiliated to Guangxi University of Chinese Medicine,Nanning 530201,China;Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 999077,China;Key Laboratory of Chinese Internal Medicine of Ministry of Education,Beijing University of Chinese Medicine,Beijing 100000,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

中国结合医学杂志（英文版）

[1]PANG Yu-zhou;TANG Jing;ZHANG Qing-huai;LIANG Feng-zhen;FANG Gang;ZHAO Chen;SHANG Hong-cai;WANG Li-ying;WANG Yan-ping-.Treatment of Psoriasis Vulgaris with Medicated Thread Moxibustion of Zhuang Medicine:A Multicenter Randomized,Parallel Controlled Trial)[J].中国结合医学杂志（英文版）,2022(03):208-214

Vulgaris,Medicated,ZMTM,pidotimod,Itch,60th,IOR

Treatment,Psoriasis,Thread,Moxibustion,Zhuang,Medicine,Multicenter,Randomized,Parallel,Controlled,Trial,Objective,To,explore,efficacy,safety,medicated,thread,moxibustion,psoriasis,vulgaris,Methods,multicenter,randomized,parallel,controlled,clinical,trial,was,designed,total,outpatients,were,randomly,divided,into,cases,treatment,using,central,block,randomization,from,June,May,treated,medicines,alone,including,dispersible,tablets,vitamin,compound,cod,liver,oil,zinc,oxide,ointment,every,days,combined,two,groups,received,continuous,intervention,primary,Area,Severity,Index,PASI,secondary,outcomes,included,Rating,Scale,Dermatology,Quality,Life,DLQI,Hamilton,Anxiety,HAMA,well,response,Meanwhile,adverse,events,evaluated,during,whole,Follow,carried,after,Results,There,shedding,this,intention,analysis,each,contained,On,30th,scores,significantly,lower,than,that,baseline,reduction,greater,scale,decreased,both,showed,better,therapeutic,effect,rates,higher,those,respectively,During,follow,improvements,No,obvious,reaction,found,either,Conclusion,without,Registration,ChiCTR

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