Objective:To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of influenza.Methods:The MEDLINE,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),Chinese Bio-medical Literature and Retrieval System(Sinomed),China National Knowledge Infrastructure Database(CNKI),China Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform and ClinicalTrails.gov were systematically searched from inception dates to May 2021 for randomized controlled trials(RCTs)exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with influenza.Statistical analysis was performed using RevMan 5.4 and Stata 15.1.The qualities of the involved studies were assessed by the risk of bias according to the Cochrane handbook.The evidence quality of each outcome was evaluated by GRADEpro GDT.Results:Twelve trials with 1,460 patients were included.The included studies had a certain unclear or high risk of bias.Reduning Injection appeared to be more effective in shortening the fever clearance time(MD:-16.20 h,95％CI:-19.40 to-12.99,7 trials,814 patients,I2=94％,very low certainty),fever alleviation time(MD:-4.09 h,95％CI:-4.22 to-3.96,3 trials,366 patients,I2=0％,low certainty),cough alleviation time(MD:-21.34 h,95％CI:-41.56 to-1.11,2 trials,228 patients,I2=89％,very low certainty),fatigue alleviation time(MD:-31.83 h,95％CI:-36.88 to-26.77,2 trials,270 patients,I2=0％,low certainty),sore throat alleviation time(MD:-28.66 h,95％CI:-32.23 to-25.10,1 trial,150 patients,low certainty),and improving the total effective rate(RR:1.15,95％CI:1.06 to 1.25,10 trials,1,074 patients,I2=76％,very low certainty).Besides,Reduning Injection seemed generally safe.Conclusions:This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be safe.Further rigorously designed studies are needed to confirm the effectiveness and safety of Reduning Injection and support it as a recommendation for influenza.

ZHAO Guo-zhen;LI Bo;WANG Ya-fan;GUO Shi-qi;DU Yuan;MA Qiu-xiao;GUO Yu-hong;LIU Qing-quan

School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Emergency,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing Evidence-Based Chinese Medicine Center,Beijing 100010,China;Beijing Institute of Chinese Medicine,Beijing 100010,China;School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Respiratory,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100700,China

中国结合医学杂志（英文版）

[1]ZHAO Guo-zhen;LI Bo;WANG Ya-fan;GUO Shi-qi;DU Yuan;MA Qiu-xiao;GUO Yu-hong;LIU Qing-quan-.Reduning Injection versus Neuraminidase Inhibitors in Treatment of Influenza:A Systematic Review and Meta-Analysis)[J].中国结合医学杂志（英文版）,2022(11):1023-1031

Reduning,Injection,versus,Neuraminidase,Inhibitors,Treatment,Influenza,Systematic,Review,Analysis,Objective,To,review,effectiveness,safety,neuraminidase,inhibitors,treatment,influenza,Methods,MEDLINE,Embase,Cochrane,Central,Register,Controlled,Trials,CENTRAL,Chinese,Bio,medical,Literature,Retrieval,Sinomed,China,National,Knowledge,Infrastructure,Database,Technology,Journal,VIP,Wanfang,Service,Platform,ClinicalTrails,gov,were,systematically,searched,from,inception,dates,May,randomized,controlled,trials,RCTs,exploring,alone,combination,patients,Statistical,analysis,was,performed,using,RevMan,Stata,qualities,involved,studies,assessed,by,risk,bias,according,handbook,evidence,quality,each,outcome,evaluated,GRADEpro,GDT,Results,Twelve,included,had,unclear,high,appeared,be,more,shortening,fever,clearance,MD,I2,very,low,certainty,alleviation,cough,fatigue,sore,throat,improving,total,rate,RR,Besides,seemed,generally,Conclusions,This,study,provided,indicating,may,might,Further,rigorously,designed,needed,confirm,support,recommendation

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