Background Metastatic lung cancer (LC) is a threat to human health. We previously proposed a fat-age-inflammation (FAIN) index which showed prognostic value in patients with certain cancers. However, whether a similar association exists in patients with metastatic LC remains unknown. Methods We performed a cohort study including 1360 patients with metastatic LC from January 2013 to April 2019. The FAIN index was defined as: (triceps skinfold thickness + albumin) / [age + 5 × (neutrophil count/lymphocyte count)] × 100％. Sex-specific cutoffs of the FAIN were determined using an optimal stratification approach. The associations of the FAIN index with the nutrition-related factors, short-term outcomes and overall survival (OS) of patients were comprehensively assessed. Results The study enrolled 865 males and 495 females with a median age of 59.9 years. The continuous FAIN was significantly associated with the OS in both genders (both P < 0.05). The optimal stratification-defined FAIN cutoffs were 82 for women and 60 for men. A total of 623 patients (45.8％) were categorized as having a low FAIN. A low FAIN was associated with poorer nutrition-related factors and impaired short-term outcomes including the thirty-day mortality, length of hospital stay, intensive care unit stay and cost (all P < 0.05). Multivariate Cox regression analysis revealed that a lower FAIN was also associated with an increased death hazard (HR = 1.428, 95％CI = 1.209-1.686). Conclusion This study assessed the FAIN index, which might act as a feasible tool to monitor nutrition-related factors and help develop management strategies to optimize the clinical outcomes of patients with metastatic LC.

Na Li;Yu Jun Zhang;Chuan Chen;Wei Li;Chun Hua Song;Han Ping Shi;Hong Xia Xu;Liang Yu Yin

Department of Clinical Nutrition,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China;Institute of Hepatopancreatobiliary Surgery,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China;Department of Cancer Center,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China;Cancer Center of the First Hospital of Jilin University,Changchun,Jilin 130021,China;Department of Epidemiology,College of Public Health,Zhengzhou University,Zhengzhou,Henan 450001,China;Department of Gastrointestinal Surgery and Department of Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China

肿瘤营养学杂志（英文）

[1]Na Li;Yu Jun Zhang;Chuan Chen;Wei Li;Chun Hua Song;Han Ping Shi;Hong Xia Xu;Liang Yu Yin-.Associations of the Fat-age-inflammation Index with Overall Survival in Patients with Metastatic Lung Cancer)[J].肿瘤营养学杂志（英文）,2022(02):32-40

FAIN,cutoffs

Associations,Fat,inflammation,Index,Overall,Survival,Patients,Metastatic,Lung,Cancer,Background,lung,LC,threat,human,health,We,previously,proposed,fat,which,showed,prognostic,value,patients,certain,cancers,However,whether,similar,exists,metastatic,remains,unknown,Methods,performed,cohort,study,including,from,January,April,was,defined,triceps,skinfold,thickness,albumin,neutrophil,count,lymphocyte,Sex,specific,were,determined,using,optimal,stratification,approach,associations,nutrition,related,factors,short,outcomes,overall,survival,OS,comprehensively,assessed,Results,enrolled,females,median,years,continuous,significantly,associated,both,genders,women,total,categorized,having,poorer,impaired,thirty,day,mortality,length,hospital,stay,intensive,care,unit,cost,Multivariate,Cox,regression,analysis,revealed,that,lower,also,increased,death,hazard,Conclusion,This,might,feasible,tool,monitor,help,develop,management,strategies,optimize,clinical

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