典型文献
Herbal Medicine Teng-Long-Bu-Zhong-Tang Inhibits the Growth of Human RKO Colorectal Cancer by Regulating Apoptosis,Senescence,and Angiogenesis
文献摘要：
Background:Teng-Long-Bu-Zhong-Tang(TLBZT)is a traditional Chinese herbal medicine used to treat colorectal cancer(CRC).In the present study,we observed the anti-cancer effects of TLBZT on human RKO CRC.Materials and Methods:Mice were subcutaneously transplanted with RKO cells,divided into control,5-Fu-administered,TLBZT-administered,and TLBZT and 5-Fu combination-administered groups,and treated with 5-Fluorouracil(5-Fu)and/or TLBZT.Apoptosis was detected by TdT-mediated dUTP nick-end labeling assay.The activity of caspase-3,-8,and-9 was detected using specific commercial kits.Cell senescence was assessed using senescence β-galactosidase staining.Protein expression was evaluated by immunohistochemistry.Results:TLBZT inhibited RKO CRC tumor growth,enhanced the anti-cancer effects of 5-Fu,induced apoptosis,and activated caspase-3,-8,and-9.TLBZT induced cell senescence accompanied by the downregulation of cyclin E1 and cyclin-dependent kinase 2 expressions.TLBZT also inhibited angiogenesis and the expression of hypoxia-inducible factor 1 subunit alpha and vascular endothelial growth factor-A.Conclusions:TLBZT inhibited RKO CRC tumor growth and enhanced the anti-cancer effects of 5-Fu,and it could be associated with apoptosis and cell senescence induction,and angiogenesis inhibition.
文献关键词：
中图分类号：
作者姓名：
Meng-Meng Wei;Shuang-Shuang Wang;Jia-Lu Zheng;Lei Chen;Xiao Peng;Jin-Fang Chen;Hong-Mei An;Bing Hu
作者机构：
Institute of Traditional Chinese Medicine in Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai;Out-patient Department,Pingdu Hospital of Traditional Chinese Medicine,Shandong;Student Affairs Department,Shanghai University of Traditional Chinese Medicine;Department of Science and Technology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,China
文献出处：
引用格式：
[1]Meng-Meng Wei;Shuang-Shuang Wang;Jia-Lu Zheng;Lei Chen;Xiao Peng;Jin-Fang Chen;Hong-Mei An;Bing Hu-.Herbal Medicine Teng-Long-Bu-Zhong-Tang Inhibits the Growth of Human RKO Colorectal Cancer by Regulating Apoptosis,Senescence,and Angiogenesis)[J].世界中医药杂志（英文版）,2022(01):110-114
A类：
TLBZT
B类：
Herbal,Medicine,Teng,Long,Bu,Zhong,Tang,Inhibits,Growth,Human,RKO,Colorectal,Cancer,by,Regulating,Apoptosis,Senescence,Angiogenesis,Background,traditional,Chinese,herbal,medicine,used,colorectal,cancer,CRC,present,study,observed,anti,effects,human,Materials,Methods,Mice,were,subcutaneously,transplanted,cells,divided,into,control,Fu,administered,combination,groups,treated,Fluorouracil,was,detected,TdT,mediated,dUTP,nick,labeling,assay,activity,caspase,using,specific,commercial,kits,Cell,senescence,assessed,galactosidase,staining,Protein,evaluated,immunohistochemistry,Results,inhibited,tumor,growth,enhanced,induced,apoptosis,activated,accompanied,downregulation,cyclin,E1,dependent,kinase,expressions,also,angiogenesis,hypoxia,inducible,subunit,alpha,vascular,endothelial,Conclusions,could,associated,induction,inhibition
AB值：
0.528644
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