Four novel pyrazole-benzene carboxamide derivatives 2a～2d were synthesized and character-ized by NMR,HRMS spectral method and X-ray diffraction analysis,and were further conducted for screening the anti-fungal/anti-oomycete activity.Compound 2d crystallizes as monoclinic space group P21/c with a=42.260(4),b=5.3751(4),c=8.0129(9)?,β=92.958(10)°,V=1817.7(3)?3,Z=4,Mr=385.41,Dc=1.408 Mg/m3,S=1.087,μ=0.773 mrr-1,F(000)=808,the final R=0.0763 and wR=0.2136 for 2657 observed reflec-tions(I＞2σ(I)).The preliminary antifungal assay indicates that the title compounds show fair to excellent anti-fungal/anti-oomycete activity toward four plant fungi and two crop oomycetes.Among them,compound 2b ex-hibits the strongest in vitro anti-B.cinerea effects(EC50=1.61 mg/L).In vivo test presents compound 2b displays considerable protective and curative effects to tomato fruits infected by B.cinerea.These results indicate that compound 2b would be potential fungicides leads for further development.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China

[1]YANG Zi-Hui;LIU Qing-Song;SUN Yue;SUN Xue-Bao;GU Wen-.Synthesis,Crystal Structure and Anti-fungal/Anti-oomycete Activity of New Pyrazole-benzene Carboxamide Derivatives)[J].结构化学,2022(03):253-259

Pyrazole,Carboxamide,mrr,oomycetes

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