典型文献
Anti-proliferative Properties of Schinensilactone A,A Schinortriterpenoid with 7,8-Seco-1,8-cyclo Scaffold against Caco-2 by Inducing Cell Apoptosis from the Leaves of Schisandra chinensis
文献摘要：
A novel schinortriterpenoid(SNT),schinensilactone A(1),characterized by a unique 7,8-seco-1,8-cyclo-schisanartane scaffold,was isolated from the leaves of Schisandra chinensis(Turcz.)Baill,together with a new SNT(schinensilactone B,2)and two known(3,4).Their structures were elucidated using spectroscopy and X-ray diffraction.Furthermore,a hypothetical biosynthetic pathway for 1 was postulated due to its novel carbon skeleton.In addition,1 exhibited significant anti-proliferative activity against Caco-2 cells originat-ing from five different tumor cell lines,and its preliminary mechanism of action was investigated with respect to the expression of apoptosis-related proteins,including P53,Caspase 3,Bax,PUMA,and Bcl2.These biological activities would further our understanding of the food function of Schisandra chinensis leaves.
文献关键词：
中图分类号：
作者姓名：
Yan Liu;Guo-Zhen Liu;Xiao-Mao Li;Peng Jiang;Yong-Gang Xia;Hai-Xue Kuang;Bing-You Yang
作者机构：
Key Laboratory of Basic and Application Research of Beiyao(Heilongjiang University of Chinese Medicine),Ministry of Education,Harbin,Heilongjiang 150040,China
文献出处：
引用格式：
[1]Yan Liu;Guo-Zhen Liu;Xiao-Mao Li;Peng Jiang;Yong-Gang Xia;Hai-Xue Kuang;Bing-You Yang-.Anti-proliferative Properties of Schinensilactone A,A Schinortriterpenoid with 7,8-Seco-1,8-cyclo Scaffold against Caco-2 by Inducing Cell Apoptosis from the Leaves of Schisandra chinensis)[J].中国化学（英文版）,2022(11):1331-1336
A类：
Schinensilactone,Schinortriterpenoid,Seco,schinortriterpenoid,schinensilactone,schisanartane,originat
B类：
Anti,proliferative,Properties,cyclo,Scaffold,against,Caco,by,Inducing,Cell,Apoptosis,from,Leaves,Schisandra,chinensis,novel,SNT,characterized,unique,seco,scaffold,was,isolated,leaves,Turcz,Baill,together,new,two,known,Their,structures,were,elucidated,using,spectroscopy,ray,diffraction,Furthermore,hypothetical,biosynthetic,pathway,postulated,due,its,carbon,skeleton,addition,exhibited,significant,anti,activity,cells,five,different,tumor,lines,preliminary,mechanism,investigated,respect,expression,apoptosis,related,proteins,including,P53,Caspase,Bax,PUMA,Bcl2,These,biological,activities,would,further,our,understanding,food,function
AB值：
0.637887
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
