典型文献
Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities
文献摘要:
Twenty-two new limonoids,mufolinoids A-V (1-22),including six rings A,B-seco limonoids (1-6),twelve ring A-seco limonoids(7-18),four ring-intact limonoids (19-22),together with thirteen known compounds (23-35) were isolated from Munronia unifo-liolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray dif-fraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug re-sistance of MCF-7/doxorubicin (DOX) cells,and the reversal fold (RF) was much higher than that of positive drug Verapamil.Com-pounds 24,28,and 29 exhibited significant anti-inflammatory activity with the ICs0 values in the range of 17.7-39.4 μmol/L.Fur-thermore,compound 29 could markedly inhibit the release of IL-1β by inhibiting the initiation and assembly of NLRP3 inflam-masome,which demonstrates the great potential of limonoids as an anti-inflammatory agent.
文献关键词:
中图分类号:
作者姓名:
Yunpeng Sun;Qiurong Li;Letian Cui;Pengfei Tang;Yongyi Li;Lingyi Kong;Jun Luo
作者机构:
Jiangsu Key Laboratory of Bioactive Natural Product Research,State Key Laboratory of Natural Medicines,Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing,Jiangsu 210009,China
文献出处:
引用格式:
[1]Yunpeng Sun;Qiurong Li;Letian Cui;Pengfei Tang;Yongyi Li;Lingyi Kong;Jun Luo-.Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities)[J].中国化学(英文版),2022(01):123-136
A类:
Limonoids,Munronia,unifoliolata,limonoids,mufolinoids,unifo,liolata,masome
B类:
Diverse,Ring,seco,from,Their,Biological,Activities,Twenty,two,new,including,six,rings,twelve,four,intact,together,thirteen,known,compounds,were,isolated,structures,absolute,configurations,elucidated,by,combination,NMR,single,crystal,ray,dif,fraction,calculations,ECD,technologies,Compounds,could,be,significantly,reversed,multidrug,sistance,MCF,doxorubicin,DOX,cells,reversal,fold,RF,was,much,higher,than,that,positive,Verapamil,exhibited,anti,inflammatory,activity,ICs0,values,range,Fur,thermore,markedly,release,inhibiting,initiation,assembly,NLRP3,which,demonstrates,great,potential,agent
AB值:
0.56857
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