典型文献
Distinctive Cassane Diterpenoids Corroborated Biogenetic Evolutionary Process from Caesalpinia mimosoides with Anti-renal Fibrosis Activity
文献摘要：
Eighteen diterpenoids were isolated from the seeds of Caesalpinia mimosoides,including four extremely infrequent cassane diter-penes,together with nine new and five known structures.Compounds 7 and 8 represent the first examples of cassane diterpenoids fused with a ketone carbonyl and a ternary oxygen ring at C-4,respectively.Compounds 9 and 10 possess a rare five-member ring in cassane diterpenes.Intriguingly,these isolated components are a clue to the fact that there are lower and higher levels in the plant secondary metabolites,demonstrating the evolution of secondary metabolism of C.mimosoides.All the isolated compounds were tested for their anti-renal fibrosis activity against TGF-β1 induced NRK-52E cell model.The mRNA levels of fibrosis marker α-SMA,E-cadherin,Collagen I were tested by qRT-PCR.The data showed compounds 6 and 9 exhibited the best anti-renal fibrosis activity and provided preliminary structure-activity relationships.
文献关键词：
中图分类号：
作者姓名：
Xinxin Zhang;Yan Yin;Yu Zhou;Tianliang Zhu;Miao Wang;Huiyuan Gao
作者机构：
School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China;Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China
文献出处：
引用格式：
[1]Xinxin Zhang;Yan Yin;Yu Zhou;Tianliang Zhu;Miao Wang;Huiyuan Gao-.Distinctive Cassane Diterpenoids Corroborated Biogenetic Evolutionary Process from Caesalpinia mimosoides with Anti-renal Fibrosis Activity)[J].中国化学（英文版）,2022(05):617-627
A类：
Cassane,Diterpenoids,Corroborated,Biogenetic,mimosoides,cassane,diter,penes,diterpenes
B类：
Distinctive,Evolutionary,Process,from,Caesalpinia,Anti,renal,Fibrosis,Activity,Eighteen,diterpenoids,were,isolated,seeds,including,four,extremely,infrequent,together,nine,new,five,known,structures,Compounds,represent,first,examples,fused,ketone,carbonyl,ternary,oxygen,ring,respectively,possess,rare,member,Intriguingly,these,components,clue,fact,that,there,lower,higher,levels,plant,secondary,metabolites,demonstrating,evolution,metabolism,All,compounds,tested,their,anti,fibrosis,activity,against,TGF,induced,NRK,52E,cell,model,marker,SMA,cadherin,Collagen,by,qRT,data,showed,exhibited,best,provided,preliminary,relationships
AB值：
0.564575
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