典型文献
Characterization of Changes and Driver Microbes in Gut Microbiota During Healthy Aging Using A Captive Monkey Model
文献摘要：
Recent population studies have significantly advanced our understanding of how age shapes the gut microbiota.However,the actual role of age could be inevitably confounded due to the complex and variable environmental factors in human populations.A well-controlled envi-ronment is thus necessary to reduce undesirable confounding effects,and recapitulate age-dependent changes in the gut microbiota of healthy primates.Herein we performed 16S rRNA gene sequenc-ing,characterized the age-associated gut microbial profiles from infant to elderly crab-eating maca-ques reared in captivity,and systemically revealed the lifelong dynamic changes of the primate gut microbiota.While the most significant age-associated taxa were mainly found as commensals such as Faecalibacterium,the abundance of a group of suspicious pathogens such as Helicobacter was exclusively increased in infants,underlining their potential role in host development.Importantly,topology analysis indicated that the network connectivity of gut microbiota was even more age-dependent than taxonomic diversity,and its tremendous decline with age could probably be linked to healthy aging.Moreover,we identified key driver microbes responsible for such age-dependent network changes,which were further linked to altered metabolic functions of lipids,carbohydrates,and amino acids,as well as phenotypes in the microbial community.The current study thus demon-strates the lifelong age-dependent changes and their driver microbes in the primate gut microbiota,and provides new insights into their roles in the development and healthy aging of their hosts.
文献关键词：
中图分类号：
作者姓名：
Zhi-Yuan Wei;Jun-Hua Rao;Ming-Tian Tang;Guo-An Zhao;Qi-Chun Li;Li-Ming Wu;Shao-Qiang Liu;Bi-Hai Li;Bai-Quan Xiao;Xing-Yin Liu;Jian-Huan Chen
作者机构：
Guangdong Key Laboratory of Animal Conservation and Resource Utilization,Guangdong Public Laboratory of Wild Animal Conservation and Utilization,Institute of Zoology,Guangdong Academy of Sciences,Guangzhou 510260,China;Laboratory of Genomic and Precision Medicine,Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China;Joint Primate Research Center for Chronic Diseases,Jiangnan University and Institute of Zoology,Guangdong Academy of Sciences,Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China;Department of Pathogen-Microbiology Division,Nanjing Medical University,Nanjing 211166,China
文献出处：
引用格式：
[1]Zhi-Yuan Wei;Jun-Hua Rao;Ming-Tian Tang;Guo-An Zhao;Qi-Chun Li;Li-Ming Wu;Shao-Qiang Liu;Bi-Hai Li;Bai-Quan Xiao;Xing-Yin Liu;Jian-Huan Chen-.Characterization of Changes and Driver Microbes in Gut Microbiota During Healthy Aging Using A Captive Monkey Model)[J].基因组蛋白质组与生物信息学报（英文版）,2022(02):350-365
A类：
Monkey,confounded,maca
B类：
Characterization,Changes,Driver,Microbes,Gut,Microbiota,During,Healthy,Aging,Using,Captive,Model,Recent,studies,have,significantly,advanced,our,understanding,how,age,shapes,gut,microbiota,However,actual,could,inevitably,due,complex,variable,environmental,factors,human,populations,well,controlled,thus,necessary,reduce,undesirable,confounding,effects,recapitulate,dependent,changes,healthy,primates,Herein,performed,16S,rRNA,gene,sequenc,characterized,associated,microbial,profiles,from,elderly,crab,eating,ques,reared,captivity,systemically,revealed,lifelong,dynamic,While,most,taxa,were,mainly,commensals,such,Faecalibacterium,abundance,group,suspicious,pathogens,Helicobacter,was,exclusively,increased,infants,underlining,their,potential,development,Importantly,topology,analysis,indicated,that,network,connectivity,even,more,than,taxonomic,diversity,its,tremendous,decline,probably,linked,aging,Moreover,identified,driver,microbes,responsible,which,further,altered,metabolic,functions,lipids,carbohydrates,amino,acids,phenotypes,community,current,study,demon,strates,provides,new,insights,into,roles,hosts
AB值：
0.609948
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