典型文献
Gut Microbiota Diversity and Overweight/Obesity in Infancy:Results from a Nested Case-control Study
文献摘要：
Objective:Childhood obesity is a major health concern worldwide.Previous studies have explored the relationship between obesity and gut microbiota.However,the results from such studies remain contradictory.Methods:In the present nested case-control study,based on a twin birth cohort study,the relationship between gut microbiota diversity and overweight/obesity in 1-and 6-month-old infants was explored.Twins were enrolled when one child had normal weight and the other child was overweight/obese at six months old.For both infants,stool samples were collected at 1 and 6 months of age.Finally,12 twins were enrolled in the study.The gut microbiota was identified by 16S rRNA gene sequencing in the V3-V4 area.Six of the twins were monozygotic.Results:The results revealed that the microbiota communities of monozygotic twins were similar to those of dizygotic twins.The relative abundance(RA)of microbiota of 1-month-old twins was significantly higher than that of 6-month-old twins.However,the microbiota diversity of 1-month-old twins was significantly lower than that of 6-month-old twins.In addition,6-month-old twins had significantly higher RA levels of Bifidobacterium and Lachnospiracea incertae sedis than 1-month-old twins.The 6-month-old group had significantly lower RA levels of Veillonella,Klebsiella,Akkermansia,Streptococcus,or Staphylococcus than the 1-month-old group.At six months,the RA level of Clostridium sensu stricto was higher in the overweight/obesity group than the normal-weight group.Conclusion:These findings imply that changes in gut microbiota diversity during infancy may contribute to the development of obesity in early infancy.
文献关键词：
中图分类号：
作者姓名：
Hong MEI;Neng LI;Yan ZHANG;Dan ZHANG;An-na PENG;Ya-fei TAN;Hui MEI;Han XIAO;Jiang-xia CAO;Jie-qiong ZHOU;Yuan-yuan ZHONG;Rui-zhen LI;Shao-ping YANG
作者机构：
Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China;The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430000,China
文献出处：
引用格式：
[1]Hong MEI;Neng LI;Yan ZHANG;Dan ZHANG;An-na PENG;Ya-fei TAN;Hui MEI;Han XIAO;Jiang-xia CAO;Jie-qiong ZHOU;Yuan-yuan ZHONG;Rui-zhen LI;Shao-ping YANG-.Gut Microbiota Diversity and Overweight/Obesity in Infancy:Results from a Nested Case-control Study)[J].当代医学科学(英文),2022(01):210-216
A类：
Infancy,monozygotic,dizygotic
B类：
Gut,Microbiota,Diversity,Overweight,Obesity,Results,from,Nested,Case,control,Study,Objective,Childhood,obesity,major,health,concern,worldwide,Previous,studies,have,explored,relationship,between,gut,microbiota,However,results,such,remain,contradictory,Methods,present,nested,case,study,birth,cohort,diversity,overweight,old,infants,was,Twins,were,enrolled,when,child,had,normal,other,obese,six,months,For,both,stool,samples,collected,age,Finally,twins,identified,by,16S,rRNA,gene,sequencing,V3,V4,area,Six,revealed,that,communities,similar,those,relative,abundance,RA,significantly,higher,than,lower,addition,levels,Bifidobacterium,Lachnospiracea,incertae,sedis,group,Veillonella,Klebsiella,Akkermansia,Streptococcus,Staphylococcus,At,Clostridium,sensu,stricto,Conclusion,These,findings,imply,changes,during,infancy,may,contribute,development,early
AB值：
0.464183
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