A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequenc-ing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lacto-bacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,dis-criminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)Ⅳ-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health.

Xiaoai Zhang;Qingzhi Zhai;Jinfeng Wang;Xiuling Ma;Bo Xing;Hang Fan;Zhiying Gao;Fangqing Zhao;Wei Liu

State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,China;Department of Obstetrics and Gynecology,First Medical Center,The General Hospital of the People's Liberation Army,Beijing 100853,China;Computational Genomics Lab,Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China;Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China;Key Laboratory of Systems Biology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China;University of Chinese Academy of Sciences,Beijing 100049,China;Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease,Beijing 100071,China

基因组蛋白质组与生物信息学报（英文版）

[1]Xiaoai Zhang;Qingzhi Zhai;Jinfeng Wang;Xiuling Ma;Bo Xing;Hang Fan;Zhiying Gao;Fangqing Zhao;Wei Liu-.Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women)[J].基因组蛋白质组与生物信息学报（英文版）,2022(02):322-333

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